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LITERATURE CITED

  • Asano T,Sasaki K,Kitano Y,Terao K,Hanazono Y. 2006. In vivo tumor formation from primate embryonic stem cells. Methods Mol Biol 329: 459467.
  • Atalay B,Bavbek M,Cekinmez M,Ozen O,Nacar A,Karabay G,Gulsen S. 2007. Antibodies neutralizing Nogo-A increase pan-cadherin expression and motor recovery following spinal cord injury in rats. Spinal Cord 45: 780786.
  • Atalay B,Bavbek M,Ozen O,Nacar A,Gulsen S,Yigitkanli K,Caner H,Altinors N. 2008. Nogo-A inhibitory peptide (NEP1-40) increases pan-cadherin expression following mild cortical contusion injury in rats. Turk Neurosurg 18: 356365.
  • Bajada S,Mazakova I,Richardson JB,Ashammakhi N. 2008. Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2: 169183.
  • Baker M. 2005. Stem cell therapy or snake oil? Nat Biotechnol 23: 14671469.
  • Bakshi A,Barshinger AL,Swanger SA,Madhavani V,Shumsky JS,Neuhuber B,Fischer I. 2006. Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation. J Neurotrauma 23: 5565.
  • Barberi T,Klivenyi P,Calingasan NY,Lee H,Kawamata H,Loonam K,Perrier AL,Bruses J,Rubio ME,Topf N,Tabar V,Harrison NL,Beal MF,Moore MA,Studer L. 2003. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 21: 12001207.
  • Bohl D,Liu S,Blanchard S,Hocquemiller M,Haase G,Heard JM. 2008. Directed evolution of motor neurons from genetically engineered neural precursors. Stem Cells 26: 25642575.
  • Brederlau A,Correia AS,Anisimov SV,Elmi M,Paul G,Roybon L,Morizane A,Bergquist F,Riebe I,Nannmark U,Carta M,Hanse E,Takahashi J,Sasai Y,Funa K,Brundin P,Eriksson PS,Li JY. 2006. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 24: 14331440.
  • Busch SA,Silver J. 2007. The role of extracellular matrix in CNS regeneration. Curr Opin Neurobiol 17: 120127.
  • Cabrera CM,Nieto A,Cortes JL,Montes RM,Catalina P,Cobo F,Barroso-Del-Jesus A,Concha A. 2007. The low rate of HLA class I molecules on the human embryonic stem cell line HS293 is associated with the APM components' expression level. Cell Biol Int 31: 10721078.
  • Caplan AI. 2007. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213: 341347.
  • Chen CP,Kiel ME,Sadowski D,McKinnon RD. 2007. From stem cells to oligodendrocytes: prospects for brain therapy. Stem Cell Rev 3: 280288.
  • Chen CT,Foo NH,Liu WS,Chen SH. 2008. Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. Pediatr neonatol 49: 7783.
  • Chernykh ER,Stupak VV,Muradov GM,Sizikov MY,Shevela EY,Leplina OY,Tikhonova MA,Kulagin AD,Lisukov IA,Ostanin AA,Kozlov VA. 2007. Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients. Bull Exp Biol Med 143: 543547.
  • Chung S,Shin BS,Hedlund E,Pruszak J,Ferree A,Kang UJ,Isacson O,Kim KS. 2006. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J Neurochem 97: 14671480.
  • Cloutier F,Siegenthaler MM,Nistor G,Keirstead HS. 2006. Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Regen Med 1: 469479.
  • Daley GQ. 2004. Missed opportunities in embryonic stem-cell research. N Engl J Med 351: 627628.
  • Dasari VR,Spomar DG,Cady C,Gujrati M,Rao JS,Dinh DH. 2007a. Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated apoptotic pathway after spinal cord injury in rats. Neurochem Res 32: 20802093.
  • Dasari VR,Spomar DG,Gondi CS,Sloffer CA,Saving KL,Gujrati M,Rao JS,Dinh DH. 2007b. Axonal remyelination by cord blood stem cells after spinal cord injury. J Neurotrauma 24: 391410.
  • Dasari VR,Spomar DG,Li L,Gujrati M,Rao JS,Dinh DH. 2008a. Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Neurochem Res 33: 134149.
  • Dasari VR,Veeravalli KK,Saving KL,Gujrati M,Fassett D,Klopfenstein JD,Dinh DH,Rao JS. 2008b. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol Dis 32: 486498.
  • De Coppi P,Bartsch G, Jr.,Siddiqui MM,Xu T,Santos CC,Perin L,Mostoslavsky G,Serre AC,Snyder EY,Yoo JJ,Furth ME,Soker S,Atala A. 2007. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25: 100106.
  • Deda H,Inci MC,Kurekci AE,Sav A,Kayihan K,Ozgun E,Ustunsoy GE,Kocabay S. 2009. Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy 11: 1825.
  • Denker HW. 2006. Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources. J Med Ethics 32: 665671.
  • Deshpande DM,Kim YS,Martinez T,Carmen J,Dike S,Shats I,Rubin LL,Drummond J,Krishnan C,Hoke A,Maragakis N,Shefner J,Rothstein JD,Kerr DA. 2006. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 60: 3244.
  • Di Nicola M,Carlo-Stella C,Magni M,Milanesi M,Longoni PD,Matteucci P,Grisanti S,Gianni AM. 2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99: 38383843.
  • Divani AA,Hussain MS,Magal E,Heary RF,Qureshi AI. 2007. The use of stem cells' hematopoietic stimulating factors therapy following spinal cord injury. Ann Biomed Eng 35: 16471656.
  • Draper JS,Smith K,Gokhale P,Moore HD,Maltby E,Johnson J,Meisner L,Zwaka TP,Thomson JA,Andrews PW. 2004. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol 22: 5354.
  • Drukker M,Katchman H,Katz G,Even-Tov Friedman S,Shezen E,Hornstein E,Mandelboim O,Reisner Y,Benvenisty N. 2006. Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells 24: 221229.
  • El-Badri NS,Hakki A,Saporta S,Liang X,Madhusodanan S,Willing AE,Sanberg CD,Sanberg PR. 2006. Cord blood mesenchymal stem cells: potential use in neurological disorders. Stem Cells Dev 15: 497506.
  • Erdo F,Buhrle C,Blunk J,Hoehn M,Xia Y,Fleischmann B,Focking M,Kustermann E,Kolossov E,Hescheler J,Hossmann KA,Trapp T. 2003. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 23: 780785.
  • Fawcett JW. 2006. Overcoming inhibition in the damaged spinal cord. J Neurotrauma 23: 371383.
  • Fitch MT,Silver J. 2008. CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 209: 294301.
  • Freund P,Schmidlin E,Wannier T,Bloch J,Mir A,Schwab ME,Rouiller EM. 2006. Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nat Med 12: 790792.
  • Gang EJ,Hong SH,Jeong JA,Hwang SH,Kim SW,Yang IH,Ahn C,Han H,Kim H. 2004. In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells. Biochem Biophys Res Commun 321: 102108.
  • Geuna S,Borrione P,Fornaro M,Giacobini-Robecchi MG. 2001. Adult stem cells and neurogenesis: historical roots and state of the art. Anat Rec 265: 132141.
  • Gokhan S,Mehler MF. 2001. Basic and clinical neuroscience applications of embryonic stem cells. Anat Rec 265: 142156.
  • Grunt RF. 2004. Embryonic stem-cell research. N Engl J Med 351: 17971798; author reply 1797–1798.
  • Habisch HJ,Janowski M,Binder D,Kuzma-Kozakiewicz M,Widmann A,Habich A,Schwalenstocker B,Hermann A,Brenner R,Lukomska B,Domanska-Janik K,Ludolph AC,Storch A. 2007. Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 114: 13951406.
  • Hamasaki T,Tanaka N,Kamei N,Ishida O,Yanada S,Nakanishi K,Nishida K,Oishi Y,Kawamata S,Sakai N,Ochi M. 2007. Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures. Spine 32: 23002305.
  • Harris DT. 2008. Cord blood stem cells: a review of potential neurological applications. Stem Cell Rev 4: 269274.
  • Harrower TP,Tyers P,Hooks Y,Barker RA. 2006. Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease. Exp Neurol 197: 5669.
  • Hochedlinger K,Jaenisch R. 2002. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature 415: 10351038.
  • Hofstetter CP,Schwarz EJ,Hess D,Widenfalk J,El Manira A,Prockop DJ,Olson L. 2002. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 99: 21992204.
  • Jan E,Kotov NA. 2007. Successful differentiation of mouse neural stem cells on layer-by-layer assembled single-walled carbon nanotube composite. Nano Lett 7: 11231128.
  • Kamei N,Tanaka N,Oishi Y,Hamasaki T,Nakanishi K,Sakai N,Ochi M. 2007. BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures. Spine 32: 12721278.
  • Kaneko S,Iwanami A,Nakamura M,Kishino A,Kikuchi K,Shibata S,Okano HJ,Ikegami T,Moriya A,Konishi O,Nakayama C,Kumagai K,Kimura T,Sato Y,Goshima Y,Taniguchi M,Ito M,He Z,Toyama Y,Okano H. 2006. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med 12: 13801389.
  • Kang KS,Kim SW,Oh YH,Yu JW,Kim KY,Park HK,Song CH,Han H. 2005. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 7: 368373.
  • Kao CH,Chen SH,Chio CC,Lin MT. 2008. Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injury by stimulating vascular endothelial and neurotrophic factors. Shock 29: 4955.
  • Karimi-Abdolrezaee S,Eftekharpour E,Wang J,Morshead CM,Fehlings MG. 2006. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci 26: 33773389.
  • Kawasaki H,Mizuseki K,Nishikawa S,Kaneko S,Kuwana Y,Nakanishi S,Nishikawa SI,Sasai Y. 2000. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28: 3140.
  • Keirstead HS,Nistor G,Bernal G,Totoiu M,Cloutier F,Sharp K,Steward O. 2005. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25: 46944705.
  • Kelsch W,Mosley CP,Lin CW,Lois C. 2007. Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. PLoS Biol 5: e300.
  • Kerr DA,Llado J,Shamblott MJ,Maragakis NJ,Irani DN,Crawford TO,Krishnan C,Dike S,Gearhart JD,Rothstein JD. 2003. Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J Neurosci 23: 51315140.
  • Kim DW,Chung S,Hwang M,Ferree A,Tsai HC,Park JJ,Chung S,Nam TS,Kang UJ,Isacson O,Kim KS. 2006. Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells 24: 557567.
  • Kuh SU,Cho YE,Yoon DH,Kim KN,Ha Y. 2005. Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat. Acta Neurochir (Wien) 147: 985992; discussion 992.
  • Kulbatski I,Mothe AJ,Keating A,Hakamata Y,Kobayashi E,Tator CH. 2007. Oligodendrocytes and radial glia derived from adult rat spinal cord progenitors: morphological and immunocytochemical characterization. J Histochem Cytochem 55: 209222.
  • Kulbatski I,Tator CH. 2009. Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation. J Histochem Cytochem 57: 405423.
  • Kwon BK,Fisher CG,Dvorak MF,Tetzlaff W. 2005. Strategies to promote neural repair and regeneration after spinal cord injury. Spine 30: S3S13.
  • Le Blanc K,Tammik C,Rosendahl K,Zetterberg E,Ringden O. 2003. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 31: 890896.
  • Lee EH,Hui JH. 2006. The potential of stem cells in orthopaedic surgery. J Bone Joint Surg Br 88: 841851.
  • Lee H,Shamy GA,Elkabetz Y,Schofield CM,Harrsion NL,Panagiotakos G,Socci ND,Tabar V,Studer L. 2007. Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 25: 19311939.
  • Lepore AC,Bakshi A,Swanger SA,Rao MS,Fischer I. 2005. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res 1045: 206216.
  • Li JY,Christophersen NS,Hall V,Soulet D,Brundin P. 2008a. Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci 31: 146153.
  • Li XJ,Du ZW,Zarnowska ED,Pankratz M,Hansen LO,Pearce RA,Zhang SC. 2005. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 23: 215221.
  • Li XJ,Hu BY,Jones SA,Zhang YS,Lavaute T,Du ZW,Zhang SC. 2008b. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26: 886893.
  • Lim JH,Byeon YE,Ryu HH,Jeong YH,Lee YW,Kim WH,Kang KS,Kweon OK. 2007. Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. J Vet Sci 8: 275282.
  • Lim PA,Tow AM. 2007. Recovery and regeneration after spinal cord injury: a review and summary of recent literature. Ann Acad Med Singapore 36: 4957.
  • Liu S,Qu Y,Stewart TJ,Howard MJ,Chakrabortty S,Holekamp TF,McDonald JW. 2000. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci USA 97: 61266131.
  • Lowry N,Goderie SK,Adamo M,Lederman P,Charniga C,Gill J,Silver J,Temple S. 2008. Multipotent embryonic spinal cord stem cells expanded by endothelial factors and Shh/RA promote functional recovery after spinal cord injury. Exp Neurol 209: 510522.
  • McDonald JW,Becker D,Holekamp TF,Howard M,Liu S,Lu A,Lu J,Platik MM,Qu Y,Stewart T,Vadivelu S. 2004. Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. J Neurotrauma 21: 383393.
  • McDonald JW,Liu XZ,Qu Y,Liu S,Mickey SK,Turetsky D,Gottlieb DI,Choi DW. 1999. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5: 14101412.
  • Meletis K,Barnabe-Heider F,Carlen M,Evergren E,Tomilin N,Shupliakov O,Frisen J. 2008. Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol 6: e182.
  • Menendez P,Bueno C,Wang L,Bhatia M. 2005. Human embryonic stem cells: potential tool for achieving immunotolerance? Stem Cell Rev 1: 151158.
  • Meng XT,Li C,Dong ZY,Liu JM,Li W,Liu Y,Xue H,Chen D. 2008. Co-transplantation of bFGF-expressing amniotic epithelial cells and neural stem cells promotes functional recovery in spinal cord-injured rats. Cell Biol Int 32: 15461558.
  • Miles GB,Yohn DC,Wichterle H,Jessell TM,Rafuse VF,Brownstone RM. 2004. Functional properties of motoneurons derived from mouse embryonic stem cells. J Neurosci 24: 78487858.
  • Mothe AJ,Tator CH. 2008. Transplanted neural stem/progenitor cells generate myelinating oligodendrocytes and Schwann cells in spinal cord demyelination and dysmyelination. Exp Neurol 213: 176190.
  • Niranjan A,Fellows W,Stauffer W,Burton EA,Hong CS,Lunsford LD,Kondziolka D,Glorioso JC,Gobbel GT. 2007. Survival of transplanted neural progenitor cells enhanced by brain irradiation. J Neurosurg 107: 383391.
  • Nisbet DR,Moses D,Gengenbach TR,Forsythe JS,Finkelstein DI,Horne MK. 2009. Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury. J Biomed Mater Res A 89: 2435.
  • Nishio Y,Koda M,Kamada T,Someya Y,Yoshinaga K,Okada S,Harada H,Okawa A,Moriya H,Yamazaki M. 2006. The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats. J Neurosurg Spine 5: 424433.
  • Ogawa Y,Sawamoto K,Miyata T,Miyao S,Watanabe M,Nakamura M,Bregman BS,Koike M,Uchiyama Y,Toyama Y,Okano H. 2002. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res 69: 925933.
  • Okada S,Nakamura M,Katoh H,Miyao T,Shimazaki T,Ishii K,Yamane J,Yoshimura A,Iwamoto Y,Toyama Y,Okano H. 2006. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12: 829834.
  • Okamura RM,Lebkowski J,Au M,Priest CA,Denham J,Majumdar AS. 2007. Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells. J Neuroimmunol 192: 134144.
  • Okita K,Ichisaka T,Yamanaka S. 2007. Generation of germline-competent induced pluripotent stem cells. Nature 448: 313317.
  • Pan HC,Cheng FC,Lai SZ,Yang DY,Wang YC,Lee MS. 2008. Enhanced regeneration in spinal cord injury by concomitant treatment with granulocyte colony-stimulating factor and neuronal stem cells. J Clin Neurosci 15: 656664.
  • Pandya SK. 2008. Stem cell transplantation in India: tall claims, questionable ethics. Indian J Med Ethics 5: 1517.
  • Pankratz MT,Li XJ,Lavaute TM,Lyons EA,Chen X,Zhang SC. 2007. Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25: 15111520.
  • Park HC,Shim YS,Ha Y,Yoon SH,Park SR,Choi BH,Park HS. 2005. Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Tissue Eng 11: 913922.
  • Parr AM,Tator CH,Keating A. 2007. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 40: 609619.
  • Perrier AL,Tabar V,Barberi T,Rubio ME,Bruses J,Topf N,Harrison NL,Studer L. 2004. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA 101: 1254312548.
  • Petit A,Sellers DL,Liebl DJ,Tessier-Lavigne M,Kennedy TE,Horner PJ. 2007. Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proc Natl Acad Sci USA 104: 1783717842.
  • Pfeifer K,Vroemen M,Caioni M,Aigner L,Bogdahn U,Weidner N. 2006. Autologous adult rodent neural progenitor cell transplantation represents a feasible strategy to promote structural repair in the chronically injured spinal cord. Regen Med 1: 255266.
  • Phinney DG. 2007. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 6: 28842889.
  • Phinney DG,Prockop DJ. 2007. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views. Stem Cells 25: 28962902.
  • Pruszak J,Sonntag KC,Aung MH,Sanchez-Pernaute R,Isacson O. 2007. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells 25: 22572268.
  • Puceat M,Ballis A. 2007. Embryonic stem cells: from bench to bedside. Clin Pharmacol Ther 82: 337339.
  • Ronsyn MW,Daans J,Spaepen G,Chatterjee S,Vermeulen K,D'Haese P,Van Tendeloo VF,Van Marck E,Ysebaert D,Berneman ZN,Jorens PG,Ponsaerts P. 2007. Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord. BMC Biotechnol 7: 90.
  • Roy NS,Cleren C,Singh SK,Yang L,Beal MF,Goldman SA. 2006. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12: 12591268.
  • Saito F,Nakatani T,Iwase M,Maeda Y,Hirakawa A,Murao Y,Suzuki Y,Onodera R,Fukushima M,Ide C. 2008. Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report. J Trauma 64: 5359.
  • Sasaki M,Honmou O,Akiyama Y,Uede T,Hashi K,Kocsis JD. 2001. Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 35: 2634.
  • Schwab ME. 2004. Nogo and axon regeneration. Curr Opin Neurobiol 14: 118124.
  • Senior K. 2000. Embryonic stem cells used to remyelinate injured rat spinal cord neurons. Lancet 355: 1890.
  • Sheth RN,Manzano G,Li X,Levi AD. 2008. Transplantation of human bone marrow-derived stromal cells into the contused spinal cord of nude rats. J Neurosurg Spine 8: 153162.
  • Shihabuddin LS,Numan S,Huff MR,Dodge JC,Clarke J,Macauley SL,Yang W,Taksir TV,Parsons G,Passini MA,Gage FH,Stewart GR. 2004. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. J Neurosci 24: 1064210651.
  • Shin S,Xue H,Mattson MP,Rao MS. 2007. Stage-dependent Olig2 expression in motor neurons and oligodendrocytes differentiated from embryonic stem cells. Stem Cells Dev 16: 131141.
  • Singh Roy N,Nakano T,Xuing L,Kang J,Nedergaard M,Goldman SA. 2005. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196: 224234.
  • Snyder EY,Daley GQ,Goodell M. 2004. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res 76: 157168.
  • Someya Y,Koda M,Dezawa M,Kadota T,Hashimoto M,Kamada T,Nishio Y,Kadota R,Mannoji C,Miyashita T,Okawa A,Yoshinaga K,Yamazaki M. 2008. Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord. J Neurosurg Spine 9: 600610.
  • Song S,Song S,Zhang H,Cuevas J,Sanchez-Ramos J. 2007. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem Cells Dev 16: 747756.
  • Sonntag KC,Pruszak J,Yoshizaki T,van Arensbergen J,Sanchez-Pernaute R,Isacson O. 2007. Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells 25: 411418.
  • Soundararajan P,Lindsey BW,Leopold C,Rafuse VF. 2007. Easy and rapid differentiation of embryonic stem cells into functional motoneurons using sonic hedgehog-producing cells. Stem Cells 25: 16971706.
  • Su H,Chu TH,Wu W. 2007. Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord. Exp Neurol 206: 296307.
  • Sykova E,Homola A,Mazanec R,Lachmann H,Konradova SL,Kobylka P,Padr R,Neuwirth J,Komrska V,Vavra V,Stulik J,Bojar M. 2006a. Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant 15: 675687.
  • Sykova E,Jendelova P,Urdzikova L,Lesny P,Hejcl A. 2006b. Bone marrow stem cells and polymer hydrogels—two strategies for spinal cord injury repair. Cell Mol Neurobiol 26: 11131129.
  • Takagi Y,Takahashi J,Saiki H,Morizane A,Hayashi T,Kishi Y,Fukuda H,Okamoto Y,Koyanagi M,Ideguchi M,Hayashi H,Imazato T,Kawasaki H,Suemori H,Omachi S,Iida H,Itoh N,Nakatsuji N,Sasai Y,Hashimoto N. 2005. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest 115: 102109.
  • Takahashi K,Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663676.
  • Thonhoff JR,Lou DI,Jordan PM,Zhao X,Wu P. 2008. Compatibility of human fetal neural stem cells with hydrogel biomaterials in vitro. Brain Res 1187: 4251.
  • Thuret S,Moon LD,Gage FH. 2006. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci 7: 628643.
  • Tomescot A,Leschik J,Bellamy V,Dubois G,Messas E,Bruneval P,Desnos M,Hagege AA,Amit M,Itskovitz J,Menasche P,Puceat M. 2007. Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats. Stem Cells 25: 22002205.
  • Vaquero J,Zurita M. 2009. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol 24: 107116.
  • Vaquero J,Zurita M,Oya S,Santos M. 2006. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration? Neurosci Lett 398: 129134.
  • Vroemen M,Caioni M,Bogdahn U,Weidner N. 2007. Failure of Schwann cells as supporting cells for adult neural progenitor cell grafts in the acutely injured spinal cord. Cell Tissue Res 327: 113.
  • Vroemen M,Weidner N,Blesch A. 2005. Loss of gene expression in lentivirus- and retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord. Exp Neurol 195: 127139.
  • Walczak P,Chen N,Eve D,Hudson J,Zigova T,Sanchez-Ramos J,Sanberg PR,Sanberg CD,Willing AE. 2007. Long-term cultured human umbilical cord neural-like cells transplanted into the striatum of NOD SCID mice. Brain Res Bull 74: 155163.
  • Watt SM,Contreras M. 2005. Stem cell medicine: umbilical cord blood and its stem cell potential. Semin Fetal Neonatal Med 10: 209220.
  • Webber DJ,Bradbury EJ,McMahon SB,Minger SL. 2007. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med 2: 929945.
  • Weissman IL. 2000. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100: 157168.
  • Wernig M,Meissner A,Foreman R,Brambrink T,Ku M,Hochedlinger K,Bernstein BE,Jaenisch R. 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448: 318324.
  • Wichterle H,Lieberam I,Porter JA,Jessell TM. 2002. Directed differentiation of embryonic stem cells into motor neurons. Cell 110: 385397.
  • Willerth SM,Arendas KJ,Gottlieb DI,Sakiyama-Elbert SE. 2006. Optimization of fibrin scaffolds for differentiation of murine embryonic stem cells into neural lineage cells. Biomaterials 27: 59906003.
  • Willerth SM,Faxel TE,Gottlieb DI,Sakiyama-Elbert SE. 2007. The effects of soluble growth factors on embryonic stem cell differentiation inside of fibrin scaffolds. Stem Cells 25: 22352244.
  • Wu S,Suzuki Y,Ejiri Y,Noda T,Bai H,Kitada M,Kataoka K,Ohta M,Chou H,Ide C. 2003. Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72: 343351.
  • Xiao J,Nan Z,Motooka Y,Low WC. 2005. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 14: 722733.
  • Xie J,Willerth SM,Li X,Macewan MR,Rader A,Sakiyama-Elbert SE,Xia Y. 2009. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 30: 354362.
  • Yan J,Xu L,Welsh AM,Hatfield G,Hazel T,Johe K,Koliatsos VE. 2007. Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. PLoS Med 4: e39.
  • Yan Y,Yang D,Zarnowska ED,Du Z,Werbel B,Valliere C,Pearce RA,Thomson JA,Zhang SC. 2005. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23: 781790.
  • Yang CC,Shih YH,Ko MH,Hsu SY,Cheng H,Fu YS. 2008. Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord. PLoS ONE 3: e3336.
  • Yoon SH,Shim YS,Park YH,Chung JK,Nam JH,Kim MO,Park HC,Park SR,Min BH,Kim EY,Choi BH,Park H,Ha Y. 2007. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells 25: 20662073.
  • Young HE,Duplaa C,Yost MJ,Henson NL,Floyd JA,Detmer K,Thompson AJ,Powell SW,Gamblin TC,Kizziah K,Holland BJ,Boev A,Van De Water JM,Godbee DC,Jackson S,Rimando M,Edwards CR,Wu E,Cawley C,Edwards PD,Macgregor A,Bozof R,Thompson TM,Petro GJ, Jr.,Shelton HM,McCampbell BL,Mills JC,Flynt FL,Steele TA,Kearney M,Kirincich-Greathead A,Hardy W,Young PR,Amin AV,Williams RS,Horton MM,McGuinn S,Hawkins KC,Ericson K,Terracio L,Moreau C,Hixson D,Tobin BW,Hudson J,Bowyer FP, III,Black AC, Jr. 2004. Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat Rec A Discov Mol Cell Evol Biol 277: 178203.
  • Zhao ZM,Li HJ,Liu HY,Lu SH,Yang RC,Zhang QJ,Han ZC. 2004. Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant 13: 113122.
  • Zurita M,Bonilla C,Otero L,Aguayo C,Vaquero J. 2008a. Neural transdifferentiation of bone marrow stromal cells obtained by chemical agents is a short-time reversible phenomenon. Neurosci Res 60: 275280.
  • Zurita M,Vaquero J. 2004. Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. Neuroreport 15: 11051108.
  • Zurita M,Vaquero J. 2006. Bone marrow stromal cells can achieve cure of chronic paraplegic rats: functional and morphological outcome one year after transplantation. Neurosci Lett 402: 5156.
  • Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C. 2008b. Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells. Transplantation 86: 845853.