The first two authors contributed equally to this work.
Hypoxia Stabilizes Microtubule Networks and Decreases Tumor Cell Chemosensitivity to Anticancer Drugs Through Egr-1
Article first published online: 18 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
The Anatomical Record
Volume 293, Issue 3, pages 414–420, March 2010
How to Cite
Peng, W.-X., Pan, F.-Y., Liu, X.-J., Ning, S., Xu, N., Meng, F.-L., Wang, Y.-Q. and Li, C.-J. (2010), Hypoxia Stabilizes Microtubule Networks and Decreases Tumor Cell Chemosensitivity to Anticancer Drugs Through Egr-1. Anat Rec, 293: 414–420. doi: 10.1002/ar.21086
- Issue published online: 18 FEB 2010
- Article first published online: 18 FEB 2010
- Manuscript Accepted: 24 OCT 2009
- Manuscript Received: 17 JUL 2009
The hypoxic environment of solid tumor causes the tumor cells survive and which could protect them from death by facilitating resistance to therapy. Here, we provide evidence that hypoxia can increase tumor cell viability and proliferation through an Egr-1-dependant pathway. Hypoxia protected the microtubules from disassembly, and Egr-1 was colocalized with microtubules in different cell cycle stages. Knockdown of Egr-1 with its siRNA overcame the protection effect of hypoxia and increased the sensitivity of tumor cells to vinblastine under hypoxic conditions. Our results suggest a novel approach for increasing the sensitivity of tumor cells to chemotherapeutics that target microtubule assembly. Anat Rec, 293:414–420, 2010. © 2010 Wiley-Liss, Inc.