Lipopolysaccharide-Induced In Vivo Activation of Follicular Dendritic Cells is Tumor Necrosis Factor Receptor-1 Independent
Article first published online: 28 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
The Anatomical Record
Volume 295, Issue 1, pages 87–90, January 2012
How to Cite
Milićević, N. M., Milićević, Ž. and Westermann, J. (2012), Lipopolysaccharide-Induced In Vivo Activation of Follicular Dendritic Cells is Tumor Necrosis Factor Receptor-1 Independent. Anat Rec, 295: 87–90. doi: 10.1002/ar.21466
- Issue published online: 14 DEC 2011
- Article first published online: 28 SEP 2011
- Manuscript Accepted: 18 JUL 2011
- Manuscript Revised: 30 JUN 2011
- Manuscript Received: 8 MAR 2011
- Ministry for Science and Technological Development of Republic of Serbia and Alexander von Humboldt-Foundation, Bonn, Germany (Institutional Academic Cooperation between Beograd and Lübeck). Grant Numbers: 175005, DEU/1033146
- follicular dendritic cells;
- tumor necrosis factor receptor-1;
It is well recognized that tumor necrosis factor receptor-1 (TNFR1) signaling pathway (with lymphotoxin-β receptor) is of critical importance for the development, activation, and clustering of follicular dendritic cells (FDCs) within the lymphoid follicles. However, further information on the molecular control of these processes is very sparse. Here, we show that intravenous application of lipopolysaccharide induces the clear and prominent morphological signs of FDC development and activation in vivo, which is independent of TNFR1 pathway. Anat Rec, 2012. © 2011 Wiley Periodicals, Inc.