Lipopolysaccharide-Induced In Vivo Activation of Follicular Dendritic Cells is Tumor Necrosis Factor Receptor-1 Independent

Authors

  • Novica M. Milićević,

    Corresponding author
    1. Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Beograd, Serbia
    • Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Višegradska 26, 11000 Beograd, Serbia
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    • Fax: +381-11-3612567

  • Živana Milićević,

    1. Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Beograd, Serbia
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  • Jűrgen Westermann

    1. Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University of Lübeck, Lübeck, Germany
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Abstract

It is well recognized that tumor necrosis factor receptor-1 (TNFR1) signaling pathway (with lymphotoxin-β receptor) is of critical importance for the development, activation, and clustering of follicular dendritic cells (FDCs) within the lymphoid follicles. However, further information on the molecular control of these processes is very sparse. Here, we show that intravenous application of lipopolysaccharide induces the clear and prominent morphological signs of FDC development and activation in vivo, which is independent of TNFR1 pathway. Anat Rec, 2012. © 2011 Wiley Periodicals, Inc.

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