Bone Marrow Stem Cell Abnormality and Diabetic Complications
Article first published online: 19 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 295, Issue 6, pages 917–921, June 2012
How to Cite
Fujimiya, M., Nagaishi, K., Yamashita, T. and Ataka, K. (2012), Bone Marrow Stem Cell Abnormality and Diabetic Complications. Anat Rec, 295: 917–921. doi: 10.1002/ar.22445
- Issue published online: 12 MAY 2012
- Article first published online: 19 MAR 2012
- Manuscript Accepted: 4 JAN 2012
- Manuscript Revised: 13 DEC 2011
- Manuscript Received: 3 OCT 2011
- bone marrow;
- mesenchymal stem cell;
- hematopoietic stem cell;
Long-lasting diabetes impairs the function of multiple organs, which consists of degeneration of various tissues with increasing apoptosis of target cells. Recently, we found that hyperglycemia induced the appearance of abnormal cells in the bone marrow and cell fusion between bone marrow-derived cells and hepatocytes, peripheral neural cells, or renal tubular cells occurred in diabetic animals. Fused cells in these organs expressed TNFα, and accelerated apoptosis, suggesting that these events might be a cause of diabetic complications. In this review, we propose a new concept that bone marrow stem cell abnormality causes diabetic complications, and this concept might provide new strategies for treatment of diabetes-associated tissue damage. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.