Branch-Based Model for the Diameters of the Pulmonary Airways: Accounting for Departures From Self-Consistency and Registration Errors
Article first published online: 24 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 295, Issue 6, pages 1027–1044, June 2012
How to Cite
Neradilek, M. B., Polissar, N. L., Einstein, D. R., Glenny, R. W., Minard, K. R., Carson, J. P., Jiao, X., Jacob, R. E., Cox, T. C., Postlethwait, E. M. and Corley, R. A. (2012), Branch-Based Model for the Diameters of the Pulmonary Airways: Accounting for Departures From Self-Consistency and Registration Errors. Anat Rec, 295: 1027–1044. doi: 10.1002/ar.22476
- Issue published online: 12 MAY 2012
- Article first published online: 24 APR 2012
- Manuscript Accepted: 6 MAR 2012
- Manuscript Received: 5 DEC 2011
- National Heart, Lung, and Blood Institute. Grant Number: NHLBI R01 HL073598
- The National Institute of Environmental Health Sciences (NIH)
- NIEHS P01 ES011617
- pulmonary airway tree;
We examine a previously published branch-based approach for modeling airway diameters that is predicated on the assumption of self-consistency across all levels of the tree. We mathematically formulate this assumption, propose a method to test it and develop a more general model to be used when the assumption is violated. We discuss the effect of measurement error on the estimated models and propose methods that take account of error. The methods are illustrated on data from MRI and CT images of silicone casts of two rats, two normal monkeys, and one ozone-exposed monkey. Our results showed substantial departures from self-consistency in all five subjects. When departures from self-consistency exist, we do not recommend using the self-consistency model, even as an approximation, as we have shown that it may likely lead to an incorrect representation of the diameter geometry. The new variance model can be used instead. Measurement error has an important impact on the estimated morphometry models and needs to be addressed in the analysis. Anat Rec,, 2012. © 2012 Wiley Periodicals, Inc.