Chronological and Morphological Study of Heart Development in the Rat

Authors

  • Salazar García Marcela,

    1. Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez
    2. Laboratorio de Citología, Escuela Nacional de Ciencias Biológicas, IPN
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  • Revilla Monsalve María Cristina,

    1. Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social
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  • Palomino Garibay Miguel Angel,

    1. Colegio Ciencia y Tecnología, Universidad Autónoma de la Ciudad de México, UACM
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  • Arteaga Martínez Manuel,

    1. Facultad de Medicina, Universidad Nacional Autónoma de México
    2. Escuela de Medicina, Universidad Panamericana
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  • Díaz-Cintra Sofía,

    1. Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Campus UNAM-Juriquilla
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  • De La Rosa-Santander Patricia,

    1. Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Campus UNAM-Juriquilla
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  • Roque-Ramírez Bladimir,

    1. División de Investigación Biomédica, Subdirección de Enseñanza e Investigación, CMN "20 de Noviembre", ISSSTE
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  • Sánchez Gómez Concepción

    Corresponding author
    1. Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez
    • Hospital Infantil de México Federico Gómez, Lab. de Investigación en Biología del Desarrollo y Teratogénesis Experimental. Dr. Márquez 162, Col. Doctores, Del. Cuauhtémoc. CP 06720, México, DF
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Abstract

Adult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.

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