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Cortical Bone Response to the Presence of Load-Bearing Percutaneous Osseointegrated Prostheses†
Article first published online: 16 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 295, Issue 9, pages 1437–1445, September 2012
How to Cite
Jeyapalina, S., Beck, J. P., Bachus, K. N. and Bloebaum, R. D. (2012), Cortical Bone Response to the Presence of Load-Bearing Percutaneous Osseointegrated Prostheses. Anat Rec, 295: 1437–1445. doi: 10.1002/ar.22533
This article is a US government work and, as such, is in the public domain in the United States of America.
- Issue published online: 16 AUG 2012
- Article first published online: 16 JUL 2012
- Manuscript Accepted: 14 JUN 2012
- Manuscript Received: 5 MAR 2012
- DOD_PRMRP. Grant Number: PR054520
- Office of Rehabilitation R&D Service, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, The Albert and Margaret Hofmann Chair, the Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT
- percutaneous osseointegrated prosthesis;
- sheep amputation model;
- mineral apposition rate;
- back-scattered electron imaging
Although the current percutaneous osseointegrated (OI) prosthetic attachment systems are novel clinical treatments for patients with limb loss, there have only been limited translational studies undertaken to date. To bridge this knowledge gap, from a larger study group of 86 animals that were implanted with a novel percutaneous OI implant construct, 33 sheep were randomly selected from the 0-, 3-, 6-, 9- and 12-month groups for histomorphometric analyses of periprosthetic cortical bone tissue. At necropsy, implanted and nonimplanted limbs were harvested and processed for the evaluation of cortical bone porosity and mineral apposition rate (MAR). The data showed a maximum increase in bone porosity within the first 3 months following implantation and then a progressive reduction in porosity to the baseline steady-state (“Time 0”) value by 12 months. The data further verified that the MAR increased during the first 6 months of implantation, reaching a plateau between 6 and 9 months, followed by a progressive decline to the baseline steady state. It was concluded that clinical load bearing and falls precautions, taken during the first 3–6 months following percutaneous OI device implantation surgery, could greatly limit bone fractures during this vulnerable time of increasing cortical bone porosity. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.