Serglycin in Health and Diseases

Authors

  • Olivia J. Scully,

    1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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  • Pei-Jou Chua,

    1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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  • Karthik S. Harve,

    1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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  • Boon-Huat Bay,

    1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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  • George W. Yip

    Corresponding author
    1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    • Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Block MD 10, Singapore 117597, Singapore
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Abstract

Serglycin is a multifunctional molecule and one of the first proteoglycans to be cloned. In this manuscript, we examine the physiological roles of serglycin in immunity, hemostasis, cell growth, apoptosis, and reproduction. In addition, we review recent studies on the involvement of serglycin in various pathological conditions, including cancer, inflammatory diseases, and platelet disorders. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.

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