Peter F. Nichol and Yukio Saijoh contributed to this work equally.
Muscle Patterning in Mouse and Human Abdominal Wall Development and Omphalocele Specimens of Humans
Article first published online: 14 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 295, Issue 12, pages 2129–2140, December 2012
How to Cite
Nichol, P. F., Corliss, R. F., Yamada, S., Shiota, K. and Saijoh, Y. (2012), Muscle Patterning in Mouse and Human Abdominal Wall Development and Omphalocele Specimens of Humans. Anat Rec, 295: 2129–2140. doi: 10.1002/ar.22556
- Issue published online: 17 NOV 2012
- Article first published online: 14 SEP 2012
- Manuscript Accepted: 26 JUL 2012
- Manuscript Revised: 21 MAY 2012
- Manuscript Received: 28 DEC 2010
- American College of Surgeons Faculty Research Fellowship 2006-2008. Grant Number: NIH KO8 1K08DK087854-01
- March of Dimes Birth Defects Foundation (FY08-427). Grant Number: NICHD (R01HD066121)
- human omphalocele;
- body wall;
- muscle development;
Human omphalocele is a congenital defect of the abdominal wall in which the secondary abdominal wall structures (muscle and connective tissue) in an area centered around the umbilicus are replaced by a translucent membranous layer of tissue. Histological examination of omphalocele development and moreover the staging of normal human abdominal wall development has never been described. We hypothesized that omphalocele is the result of an arrest in the secondary abdominal wall development and predicted that we would observe delays in myoblast maturation and an arrest in secondary abdominal wall development. To look for evidence in support of our hypothesis, we performed a histological analysis of normal human abdominal wall development and compared this to mouse. We also conducted the first histological analysis of two human specimens with omphalocele. In these two omphalocele specimens, secondary abdominal wall development appears to have undergone an arrest around Carnegie Stage 19. In both specimens disruptions in the unidirectional orientation of myofibers were observed in the external and internal obliques, and rectus abdominis but not in the transversus abdominis. These latter findings support a model of normal abdominal wall development in which positional information instructs the orientation of myoblasts as they organize into individual muscle groups. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.