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LITERATURE CITED

  • Adunka O, Gstoettner W, Hambek M, Unkelbach MH, Radeloff A, Kiefer J. 2004a. Preservation of basal inner ear structures in cochlear implantation. ORL J Otorhinolaryngol Relat Spec 6: 306312.
  • Adunka O, Kiefer J. 2006. Impact of electrode insertion depth on intracochlear trauma. Otolaryngol Head Neck Surg 135: 374382.
  • Adunka O, Unkelbach MH, Mach M, Hambek M, Gstoettner W, Kiefer J. 2004b. Cochlear implant via the round window membrane minimizes trauma to cochlear structure: a histologically controlled insertion study. Acta Otolaryngol 124: 807812.
  • Adunka OF, Buchman CA. 2007. Scala tympani cochleostomy. I. Results of a survey. Laryngoscope 117: 21872194.
  • Adunka OF, Pillsbury HC, Buchman CA. 2010. Minimizing intracochlear trauma during cochlear implantation. Adv Otorhinolaryngol 67: 96107.
  • Adunka OF, Pillsbury HC, Kiefer J. 2006. Combining perimodiolar electrode placement and atraumatic insertion properties in cochlear implantation—fact or fantasy? Acta Otolaryngol 126: 475482.
  • Adunka OF, Radeloff A, Gstoettner WK, Pillsbury HC, Buchman CA. 2007. Scala tympani cochleostomy. II. Topography and histology. Laryngoscope 117: 21952200.
  • Aminopour S, Tinling SP, Brodie HA. 2005. Role of tumor necrosis factor-alpha in sensorineural hearing loss after bacterial meningitis. Otol Neurotol 26: 602609.
  • Angeli SI. Hyaluronate gel stapedotomy. 2006. Otolaryngol Head Neck Surg 134: 225231.
  • Anniko M, Hellstrom S, Laurent C. 1987. Reversible changes in inner ear function following hyaluronan application in the middle ear. Acta Otolaryngol Suppl 442: 7275.
  • Assi K, Pillai R, Gómez-Muñoz A, Owen D, Salh B. 2006. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology 118: 112121.
  • Balkany TJ, Connell SS, Hodges AV, Payne SL, Telischi FF, Eshraghi AA, Angeli SI, Germani R, Messiah S, Arheart KL. 2006. Conservation of residual acoustic hearing after cochlear implantation. Otol Neurotol 27: 10831088.
  • Bas E, Gupta C, Van De Water TR. A novel organ of Corti explant model for the study of cochlear implantation trauma. Anat Rec 00: 000000.
  • Baumgartner WD, Jappel A, Morera C, Gstöttner W, Müller J, Kiefer J, van de Heyning P, Anderson I, Nielsen SB. 2007. Outcomes in adults implanted with the FLEXsoft electrode. Acta Otolaryngol 127: 579586.
  • Barkdull GC, Hondarrague Y, Meyer T, Harris JP, Keithley EM. 2007. AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis. Laryngoscope 117: 21742182.
  • Barriat S, Poirrier Q, Malgrange B, Lefebvre P. 2010. Hearing preservation in cochlear implantation and drug treatment. Cochlear implants and hearing preservation. Adv Otorhinolaryngol 67: 613.
  • Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 1368113686.
  • Berrettini S, Forli F, Passetti S. 2008. Preservation of residual hearing following cochlear implantation: comparison between three surgical techniques. J Laryngol Otol 122: 246252
  • Bjurström S, Slepecky N, Angelborg C. 1987. A histopathological study of the inner ear after the administration of hyaluronan into the middle ear of the guinea pig. Acta Otolaryngol (Suppl) 104: 6265.
  • Blink E, Maianski NA, Alnemri ES, Zervos AS, Roos D, Kuijpers TW. 2004. Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils. Cell Death Differ 11: 937939.
  • Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 6: 7988.
  • Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF. 2001. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50: 7782.
  • Braun S, Ye Q, Radeloff A, Kiefer J, Gstöettner W, TIllein J. 2011. Protection of inner ear function after cochlear implantation: compound action potential measurements after local application of glucocorticoids in the guinea pig cochlea. ORL J Otorhinolaryngol Relat Spec 73: 219228.
  • Briggs RJS, Tykocinski M, Stidham K, Roberson JB. 2005. Cochleostomy site: implication for electrode placement and hearing preservation. Acta Otolaryngol 125: 870876.
  • Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. 1999. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269290.
  • Budenz CL, Pfingst BE, Rapheal Y. The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes. Anat Rec 00: 000000.
  • Candé C, Cecconi F, Dessen P, Kroemer G. 2001. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 115: 47274734.
  • Candé C, Vahsen N, Garrido C, Kroemer G. 2004. Apoptosis-inducing factor (AIF): caspase-independent after all. Cell Death Differ 11: 591595.
  • Chang A, Eastwood H, Sly D, James D, Richardson R, O'Leary S. 2009. Factors influencing the ef?cacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery. Hear Res 255: 6772.
  • Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505512.
  • Choi CH, Oghalai JS. 2005. Predicting the effect of post-implant cochlear fibrosis on residual hearing. Hear Res 205: 193200.
  • Clark GM, Shute SA, Shepherd RK, Carter TD. 1995. Cochlear implantation: osteoneogenesis, electrode-tissue impedance, and residual hearing. Ann Otol Rhinol Laryngol Suppl 166: 4042.
  • Cohen M, Meisser A, Haenggeli L, Bischof P. 2006. Involvement of MAPK pathway in TNF-a-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod 12: 225232.
  • Cohen NL. 1997. Cochlear implant soft surgery: fact or fantasy? Otolaryngol Head Neck Surg 117: 214216.
  • Cohen-Salmon M, Ott T, Michel V, Hardelin JP, Perfettini I, Eybalin M, Wu T, Marcus DC, Wangemann P, Willecke K, Petit C. 2002. Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol 12: 11061111.
  • Connolly TM, Eastwood H, Kel G, Lisnichuk H, Richardson R, O'Leary S. 2011. Pre-operative intravenous dexamethasone prevents auditory threshold shifts in a guinea pig model of cochlear implantation. Audiol Neurootol 16: 137144.
  • Cruvinel WM, Mesquita D, Jr., Araújo JA, Catelan TT, de Souza AW, da Silva NP, Andrade LE. 2010. Immune system. I. Fundamentals of innate immunity with emphasis on molecular and cellular mechanisms of inflammatory response. Brasil J Rheumatol 50: 434461.
  • Dawson VL, Dawson TM. 2004. Deadly conversations: nuclear-mitochondrial cross-talk. J Bioenerg Biomembr 36: 287294.
  • Deng Y, Ren X, Yang L, Lin Y, Wu X. 2003. A JNK-dependent pathway is required for TNF alpha-induced apoptosis. Cell 115: 6170.
  • Dinh C, Hoang K, Haake S, Chen S, Angeli S, Nong E, Eshraghi AA, Balkany TJ, van de Water TR. 2008a. Biopolymer-released dexamethasone prevents tumor necrosis factor alpha-induced loss of auditory HCs in vitro: implications toward the development of a drug-eluting cochlear implant electrode array. Otol Neurotol 29: 10121019.
  • Dinh CT, Bas E, Chan SS, Dinh JN, Vu L, van de Water TR. 2011. Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor HC survival. Neuroscience 188: 157167.
  • Dinh CT, Haake S, Chen S, Hoang K, Nong E, Eshraghi AA, Balkany TJ, van de Water TR. 2008b. Dexamethasone protects organ of Corti explants against tumor necrosis factor-alpha-induced loss of auditory HCs and alters the expression levels of apoptosis-related genes. Neuroscience 157: 405413.
  • Doolittle ND, Muldoon LL, Brummett RE, Tyson RM, Lacy C, Bubalo JS, Kraemer DF, Heinrich MC, Henry JA, Neuwelt EA. 2001. Delayed sodium thiosulfate as an otoprotectant against carboplatin-induced hearing loss in patients with malignant brain tumors. Clin Cancer Res 7: 493500.
  • Du C, Fang M, Li Y, Li L, Wang X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 3342.
  • Duan M, Qiu J, Laurell G, Olofsson A, Counter SA, Borg E. 2004. Dose and time-dependent protection of the antioxidant N-L-acetylcysteine against impulse noise trauma. Hear Res 192: 19.
  • Eastwood H, Chang A, Kel G, Sly D, Richardson R, O'Leary SJ. 2010a. Round window delivery of dexamethasone ameliorates local and remote loss produced by cochlear implantation into the second turn of the guinea pig cochlea. Hear Res 265: 2529.
  • Eastwood H, Pinder D, James D, Chang A, Galloway S, Richardson R, O'Leary S. 2010b. Permanent and transient effects of locally delivered n-acetyl cysteine in a guinea pig model of cochlear implantation. Hear Res 259: 2430.
  • Edinger AL, Thompson CB. 2004. Death by design: apoptosis, necrosis, and autophagy. Curr Opin Cell Biol 16: 663669.
  • Egger L, Schneider J, Rhême C, Tapernoux M, Häcki J, Borner C. 2003. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ 10: 11881203.
  • Erixon E, Högstorp H, Wadin K, Rask-Andersen H. 2009. Variational anatomy of the human cochlea: implications for cochlear implantation. Otol Neurotol 30: 1422.
  • Eshraghi AA, Polak M, He J, Telischi FF, Balkany TJ, van de Water TR. 2005. Pattern of hearing loss in a rat model of cochlear implantation trauma. Otol Neurotol 26: 442447.
  • Eshraghi AA. 2006. Prevention of cochlear implant electrode damage. Curr Opin Otolaryngol Head Neck Surg 14: 323328.
  • Eshraghi AA, Dinh CT, Bohorquez J, Angeli S, Abi-Hachem R, van de Water TR. 2011. Local drug delivery to conserve hearing: mechanisms of action of eluted dexamethasone within the cochlea. Cochlear Implants Internat 12: S51–S53.
  • Eshraghi AA, Gupta C, Ozdamar O, Balkany TJ, Truy E, Nazarian R. Biomedical engineering principles of modern cochlear implants and recent surgical innovations. Anat Rec 00: 000000.
  • Eshraghi AA, Wang J, Adil E, He J, Zine A, Bublik M, Bonny C, Puel JL, Balkany TJ, van de Water TR. 2007. Blocking c-Jun N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity. Hear Res 226: 168177.
  • Evans AJ, Thompson BC, Wallace GG, Millard R, O'Leary SJ, Clark GM, Shepherd RK, Richardson RT. 2009. Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes. J Biomed Mater Res A 91: 241250.
  • Farahmand-Ghavi F, Mirzadeh H, Imani M, Jolly C, Farhadi M. 2010. Corticosteroid-releasing cochlear implant: a novel hybrid of biomaterial and drug delivery system. J Biomed Mater Res B Appl Biomater 94: 388398.
  • Faris M, Kokot N, Latinis K, Kasibhatla S, Green DR, Koretzky GA, Nel A. 1998b. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J Immunol 160: 134144.
  • Faris M, Latinis KM, Kempiak SJ, Koretzky GA, Nel A. 1998a. Stress-induced Fas ligand expression in T cells in mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol Cell Biol 18: 54145424.
  • Fraysse B, Macías AR, Sterkers O, Burdo S, Ramsden R, Dequine O, Klenzner T, Lenarz T, Rodriguez MM, von Wallenberg E, James C. 2006. Residual hearing conservation and electroacoustic stimulation with the nucleus 24 contour advance cochlear implant. Otol Neurotol 27: 624633.
  • Friedland DR, Runge-Samuelson C. 2009. Soft cochlear implantation: rationale for the surgical approach. Trends Amplif 13: 124138.
  • Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H. 2006. Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res 83: 575583.
  • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Nehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, van de Nabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. 2012. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death. Cell Death Differ 19: 107120.
  • Gantz BJ, Turner C, Gfeller KE, Lowder MW. 2005. Preservation of hearing in cochlear implant surgery: advantages of combined electrical and acoustical speech processing. Laryngoscope 115: 796802.
  • Garcia-Ibanez L, Macias AR, Morera C, Rodriguez MM, Szyfter W, Skarszynski H, Emamdjomeh H, Baumgartner WD. 2009. An evaluation of the preservation of residual hearing with the Nucleus Countour Advance electrode. Acta Otolaryngol 129: 651664.
  • Gfeller KE, Olszewski C, Turner C, Gantz B, Oleson J. 2006. Music perception with cochlear implants and residual hearing. Audiol Neurootol 11: 1215.
  • Green SH, Bailey E, Wang Q, Davis RL. The Trk A, B, C's of neurotrophins in the cochlea. Anat Rec 00: 000000.
  • Griffith TS, Rauch CT, Smolak PJ, Waugh JY, Boiani N, Lynch DH, Smith CA, Goodwin RG, Kubin MZ. 1999. Functional analysis of TRAIL receptors using monoclonal antibodies. J Immunol 162: 25972605.
  • Gstöttner W, Helbig S, Maier N, Kiefer J, Radeloff A, Adunka O. 2006. Ipsilateral electric acoustic stimulation of the auditory system: results of long-term hearing preservation. Audiol Neurotol 11( Suppl 1): 4956.
  • Gstöttner W, Helbig S, Settevendemie C, Baumann U, Wagenblast J, Arnoldner C. 2009. A new electrode for residual hearing preservation in cochlear implantation: first clinical results. Acta Otolaryngol 129: 372379.
  • Gstöttner W, Plenk H, Jr., Franz P, Hamzavi J, Baumgartner W, Czerny C, Ehrenberger K. 1997. Cochlear implant deep electrode insertion: extent of insertional trauma. Acta Otolaryngol 117: 274277.
  • Gstöttner WK, Hamzavi J, Baumgartner WD, Czerny CC. 2000. Fixation of the electrode array with bone paté in cochlear implant surgery. Acta Otolaryngol 120: 369374.
  • Gstöttner, WK, van de Heyning P, Fitzgerlad O'Connor A, Morera C, Sainz M, Vermeire K, McDonald S, Cavalle L, Helbig S, Valdecasas JG, Anderson I, Adunka OF. 2008. Electric acoustic stimulation of the auditory system: results of a multicentre investigation. Acta Otolaryngol 128: 968975.
  • Ha HC, Snyder SH. 1999. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 96: 1397813982.
  • Haake SM, Dinh CT, Chen S, Eshraghi AA, van de Water TR. 2009. Dexamethasone protects auditory HCs against TNF alpha-initiated apoptosis via activation of PI3K/Akt and NF-kappa B signaling. Hear Res 255: 2232.
  • Han W, Shi X, Nuttall AL. 2006. AIF and Endo G translocation in noise exposure induced HC death. Hear Res 211: 8595.
  • Hara M, Nomura Y, Saito K. 1990. Histopathologic study of perilymph-suctioned labyrinth. Ann Otol Rhinol Laryngol 99: 316320.
  • Harris KC, Hu B, Hangauer D, Henderson D. 2005. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res 208: 1425.
  • Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES. 2002. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J Biol Chem 277: 432438.
  • Helbig S, Baumann U, Hey C, Helbig M. 2011b. Hearing preservation after complete cochlear coverage in cochlear implantation with the free-fitting FLEXSOFT electrode carrier. Otol Neurotol 32: 973979.
  • Helbig S, van de Heyning P, Kiefer J, Baumann U, Kleine-Punte A, Brockmeier H, Anderson I, Gstoettner W. 2011. Combined electric acoustic stimulation with the PULSARCI(100) implant system using the FLEX(EAS) electrode array. Acta Otolaryngol 131: 585595.
  • Henderson D, Bielefeld EC, Harris KC, Hu BH. 2006. The roles of oxidative stress in noise-induced hearing loss. Ear Hear 27: 119.
  • Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770776.
  • Hequembourg S, Liberman MC. 2001. Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice. J Assoc Res Otolaryngol 2: 118129.
  • Hirose K, Liberman MC. 2003. Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea. J Assoc Res Otolaryngol 4: 339352.
  • Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J. 2000. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1: 489495.
  • Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV. 1996a. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387396.
  • Hsu H, Shu HB, Pan MG, Goeddel DV. 1996b. TRADD-TRAF2 and TRADD-FADD interaction define two distinct TNF receptor 1 signal transduction pathways. Cell 84: 299308.
  • Hsu H, Xiong J, Goeddel DV. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495504.
  • Hu BH, Henderson D, Nicotera TM. 2002. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res 166: 6271.
  • Ichimiya I, Yoshida K, Hiranno T, Suzuki M, Mogi G. 2000. Significance of spiral ligament fibrocytes with cochlear inflammation. Int J Pediatr Otorhinolaryngol 56: 4551.
  • Itoh N, Nagata S. 1993. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268: 1093210937.
  • James C, Albegger K, Battmer R, Burdo S, Deggouj N, Dequine O, Dillier N, Gersdorff M, Laszig R, Lenarz T, Rodriguez MM, Mondain M, Offeciers E, Macías AR, Ramsden R, Sterkers O, von Wallenberg E, Weber B, Fraysse B. 2005. Preservation of residual hearing with cochlear implantation: how and why. Acta Otolaryngol 125: 481491.
  • James DP, Eastwood H, Richardson RT, O'Leary SJ. 2008. Effects of round window dexamethasone on residual hearing in a guinea pig model of cochlear implantation. Audiol Neurootol 13: 8696.
  • Jolly C, Garnham C, Mirzadeh H, Truy E, Martini A, Kiefer J, Braun S. 2009. Electrode features for hearing preservation and drug delivery strategies. Adv Otorhinolaryngol 67: 2842.
  • Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zúñiga-Pflücker JC, Kroemer G, Penninger JM. 2001. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410: 549554.
  • Kannan K, Jain SK. 2000. Oxidative stress and apoptosis. Pathophysiology 7: 153163.
  • Kawahara A, Ohsawa Y, Matsumura H, Uchiyama Y, Nagata S. 1998. Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol 143: 13531360.
  • Kiefer J, Gstoettner W, Baumgartner W, Pok SM, Tillein J, Ye Q, von Ilberg C. 2004. Conservation of low-frequency hearing in cochlear implantation. Acta Otolaryngol 124: 272280.
  • Kiefer J, Ye Q, Tillein J, Adunka O, Arnold W, Gstöettner W. 2007. Protecting the cochlea during stapes surgery: is there a role for corticosteroids? Adv Otorhinolaryngol 65: 300307.
  • Kleine Punte A, Vermeire K, van de Heyning P. 2010. Bilateral electric acoustic stimulation: a comparison of partial and deep cochlear electrode insertion. In: van de Heyning P, Kleine Punte A, editors. Cochlear implants and hearing preservation. Adv Otorhinolaryngol. Basel: Karger. Vol. 67: p 144152.
  • Kontorinis G, Paasche G, Lenarz T, Stöver T. 2011. The effect of different lubricants on cochlear implant electrode insertion forces. Otol Neurotol 32: 10501056.
  • Kopke RD, Weisskopf PA, Boone JL, Jackson RL, Wester DC, Hoffer ME, Lambert DC, Charon CC, Ding DL, McBride D. 2000. Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res 149: 138146.
  • Kopke RD, Jackson RL, Coleman JK, Liu J, Bielefeld EC, Balough BJ. 2007. NAC for noise: from the bench top to the clinic. Hear Res 226: 114125.
  • Kopke R, Bielefeld E, Liu J, Zheng J, Jackson R, Henderson D, Coleman JK. 2005. Prevention of impulse noise-induced hearing loss with antioxidants. Acta Otolaryngol 125: 235243.
  • Kramer S, Dreisbach L, Lockwood J, Baldwin K, Kopke R, Scranton S, O'Leary M. 2006. Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music. J Am Acad Audiol 17: 265278.
  • Lamm K, Arnold W. 2000. The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic pO(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Hear Res 141: 199219.
  • Lander HM, Jacovina AT, Davis RJ, Tauras JM. 1996. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J Biol Chem 271: 1970519709.
  • Laszig R, Ridder GJ, Fradis M. 2002. Intracochlear insertion of electrodes using hyaluronic acid in cochlear implant surgery. J Laryngol Otol 116: 371372.
  • Laurent C, Anniko M, Hellström S. 1991. Hyaluronan applied to lesioned round windo membrane is free from cochlear toxicity. Acta Otolaryngol 111: 506514.
  • Lee J, Nadol JB, Jr., Eddington DK. 2011. Factors associated with incomplete insertion of electrodes in cochlear implant surgery: a histopathologic study. Audiol Neurootol 16: 6981.
  • Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC, Choi Y. 1997. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 7: 703713.
  • Lehnhardt E. 1993. Intracochlear placement of cochlear implant electrodes in soft surgery technique. HNO 41: 356359.
  • Lenarz T, Stover T, Buechner A, Paasche G, Briggs R, Risi F, Pesch J, Battmer RD. 2006. Temporal bone results and hearing preservation with a new straight electrode. Audiol Neurootol 11: 3441.
  • Lorens A, Polak M, Piotrowska A, Skarzynski H. 2008. Outcomes of treatment of partial deafness with cochlear implantation: a DUET study. Laryngoscope 118: 288294.
  • Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. 2002. The Bax subfamily of Bcl-2 related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 22: 49294942.
  • Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. 2009. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci 10: 112.
  • Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491501.
  • Li LY, Luo X, Wang X. 2001. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412: 9599.
  • Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. 2006. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24: 99146.
  • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479489.
  • Li PM, Wang H, Northrop C, Merchant SN, Nadol JB, Jr. 2007. Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures. Otol Neurotol 28: 641648.
  • Lin AH, Luo J, Mondshein LH, ten Dijke P, Vivien D, Contag CH, Wyss-Coray T. 2005. Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol 175: 547554.
  • Lo YY, Wong JM, Cruz TF. 1996 Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases. J Biol Chem 271: 1570315707.
  • Lockwood DS, Ding DL, Wang J, Salvi RJ. 2000. D-Methionine attenuates inner HC loss in carboplatin-treated chinchillas. Audiol Neurootol 5: 263266.
  • Marderstein EL, Bucher B, Guo Z, Feng X, Reid K, Geller DA. 2003. Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase. Surgery 134: 280284.
  • Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downard J. 2002. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem 277: 439444.
  • McElveen JT, Wolford RD, Miyamoto RT. 1995. Implications of bone pâté in cochlear implant surgery. Otolaryngol Head Neck Surg 112: 457460.
  • Minutoli L, Altavilla D, Marini H, Passaniti M, Bitto A, Seminara P, Venuti FS, Famulari C, Macrì A, Versaci A, Squadrito F. 2004. Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. Life Sci 75: 28532866.
  • Nadol JB Jr, Shiao JY, Burgess BJ, Ketten DR, Eddington DK, Gantz BJ, Kos I, Montandon P, Coker NJ, Roland JT Jr, Shallop JK. 2011. Histopathology of cochlear implants in humans. Ann Otol Rhinol Laryngol 110: 883891.
  • Nagata S. 1999. Fas ligand-induced apoptosis. Annu Rev Genet 33: 2955.
  • Nicotera TM, Hu BH, Henderson D. 2003. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol 4: 466477.
  • Ohinata Y, Miller JM, Altschuler RA, Schacht J. 2000. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res 878: 163173.
  • Ohlemiller KK, Wright JS, Dugan LL. 1999. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 4: 229236.
  • Pantano C, Shrivastava P, McElhinney B, Janssen-Heininger Y. 2003. Hydrogen peroxide signaling through tumor necrosis factor receptor-1 leads to selective activation of c-Jun N-terminal kinase. J Biol Chem 278: 4409144096.
  • Pau HW, Just T, Bornitz M, Lasurashvilli N, Zahnert T. 2007. Noise exposure of the inner ear during drilling a cochleostomy for cochlear implantation. Laryngoscope 117: 535540.
  • Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J. 2000. Rescue of hearing, auditory HCs, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 20: 4350.
  • Postelmans JT, van Spronsen E, Grolman W, Stokroos RJ, Tange RA, Maré JM, Dreschler WA. 2011. An evaluation of preservation of residual hearing using the suprameatal approach for cochlear implantation: can this implantation technique be used for preservation of residual hearing? Laryngoscope 121: 17941799.
  • Prentiss S, Sykes K, Staecker H. 2010. Partial deafness cochlear implantation at the University of Kansas: techniques and outcomes. J Am Acad Audiol 21: 197203.
  • Prunell GF, Svendgaard NA, Alkass K, Mathiesen T. 2005. Inflammation in the brain after experimental subarachnoid hemorrhage. Neurosurgery 56: 10821092.
  • Pujol R, Puel JL, Gervais d'Aldin C, Eybalin M. 1993. Pathophysiology of glutamatergic synapses in the cochlea. Acta Otolaryngol 113: 330334.
  • Radeloff A, Unkelbach MH, Tillein J, Braun S, Helbig S, Gstöttner W, Adunka OF. 2007. Impact of intrascalar blood on hearing. Laryngoscope 117: 5862.
  • Rask-Andersen H, Liu W, Erixon E, Kinnefors A, Pfaller K, Schrott-Fisher A, Glueckert R. The human cochlea anatomical characteristics and their relevance for cochlear implantation. Anat Rec 00: 000000.
  • Richardson RT, Wise AK, Thompson BC, Flynn BO, Atkinson PJ, Fretwell NJ, Fallon JB, Wallace GG, Shepherd RK, Clark GM, O'Leary SJ. 2009. Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. Biomaterials 30: 26142624.
  • Roberson JB. 2005. Cochlear implant surgery: minimally invasive technique. Oper Tech Otolaryngol 16: 7477.
  • Rodriguez J, Lazebnik Y. 1999. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev 13: 31793184.
  • Roland JT, Jr., Magardino TM, Go JT, Hillman DE. 1995. Effects of glycerin, hyaluronic acid, and hydroxypropyl methylcellulose on the spiral ganglion of the guinea pig cochlea. Ann Otol Rhinol Laryngol (Suppl 1) 66: 6468.
  • Roland PS, Gstöttner W, Adunka O. 2005. Method for hearing preservation in cochlear implant surgery. Oper Tech Otolaryngol 16: 93100.
  • Sadrzadeh SM, Anderson DK, Panter SS, Hallaway PE, Eaton JW. 1987. Hemoglobin potentiates central nervous sytem damage. J Clin Invest 79: 662664.
  • Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. 2002. Tumor necrosis factor-alpha, an initiator, and etanercept, an inhibitor of cochlear inflammation. Laryngoscope 112: 16271634.
  • Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. 2003. Proinflammatory cytokine expression in the endolymphatic sac during inne ear inflammation. J Assoc Res Otolaryngol 4: 139147.
  • Sauer G, Richter CP, Klinke R. 1999. Sodium, potassium, chloride and calcium concentrations measured in pigeon perilymph and endolymph. Hear Res 129: 16.
  • Seki M, Miyasaka H, Edamatsu H, Watanabe K. 2001. Changes in permeability of strial vessels following vibration given to auditory ossicle by drill. Ann Otol Rhinol Laryngol 110: 112126.
  • Sercombe R, Dinh YR, Gomis P. 2002. Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn J Pharmacol 88: 227249.
  • Sharma N, Suzuki H, He Q, Sharma RP. 2005. Tumor necrosis factor alpha-mediated activation of c-Jun NH(2)-terminal kinase as a mechanism for fumonisin B(1) induced apoptosis in murine primary hepatocytes. J Biochem Mol Toxicol 19: 359367.
  • Skarzynski H, Lorens A. 2010a. Electric acoustic stimulation in children. In: van de Heyning P, Kleine Punte A, editors. Cochlear implants and hearing preservation. Adv Otorhinolaryngol. Basel: Karger. Vol. 67. p 135143.
  • Skarzynski H, Lorens A. 2010b. Partial Deafness Treatment. Cochlear implants international, 11: 2941.
  • Skarzynski H, Lorens A, D'Haese P, Walkowiak A, Piotrowska A, Sliwa L, Anderson I. 2002. Preservation of residual hearing in children and post-lingually deafened adults after cochlear implantation: an initial study. ORL J Otorhinolaryngol Relat Spec 64: 247253.
  • Skarzynski H, Lorens A, Piotrowska A. 2003. A new method of partial deafness treatment. MedSciMonit 9: 2024.
  • Skarzynski H, Lorens A, Piotrowska A, Anderson I. 2007a. Preservation of low frequency hearing in partial deafness cochlear implantation (PDCI) using the round window surgical approach. Acta Otolaryngol 127: 4148.
  • Skarzynski H, Lorens A, Piotrowska A, Anderson I. 2007b. Partial deafness cochlear implantation in children. Int J Pediatr Otorhinolaryngol 71: 14071413.
  • Skarzynski H, Lorens A, Zgoda M, Piotrowska A, Skarzynski PH, Szkielkowska A. 2011. Atraumatic round window deep insertion of cochlear electrodes. Acta Otolaryngol 131: 740749.
  • So H, Kim HJ, Lee JH, Park C, Kim Y, Kim E, Kim JK, Yun KJ, Lee KM, Lee HY, Moon SK, Lim DJ, Park R. 2007. Cisplatin cytotoxicity of auditory HCs requires secretions of proinflammatory cytokines via activation of ERK and NF-κB. J Assoc Res Otolaryngol 8: 338355.
  • Soda-Merhy A, Gonzalez-Valenzuela L, Tirado-Gutierrez C. 2008. Residual hearing preservation after cochlear implantation: comparison between straight and perimodiolar implants. Otolaryngol Head Neck Surg 139: 399404.
  • Souter MA, Briggs RJ, Wright CG, Roland PS. 2011. Round window insertion of precurved perimodiolar electrode arrays: how successful is it? Otol Neurotol 32: 5863.
  • Sperandio S, de Belle I, Bredesen DE. 2000. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci USA 97: 1437614381.
  • Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES. 2000. Molecular determinants of caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem 275: 3615236157.
  • Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES. 2001. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410: 112116.
  • Staecker H, Jolly C, Garnham C. 2010. Cochlear implantation: an opportunity for drug development. Drug Discov Today 15: 314321.
  • Susan SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Manglion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441446.
  • Sutinen P, Zou J, Hunter LL, Toppila E, Pyykkö I. 2007. Vibration-induced hearing loss: mechanical and physiological aspects. Otol Neurotol. 28: 171177.
  • Takeuchi S, Ando M, Kakigi A. 2000. Mechanism generating endocochlear potential: role played by intermediate cells in stria vascularis. Biophys J 79: 25722582.
  • Tartaglia LA, Ayres TM, Wong GH, Goeddel DV. 1993. A novel domain within the 55 kD TNF receptor signals cell death. Cell 74: 845853.
  • Teubner B, Michel V, Pesch J, Lautermann J, Cohen-Salmon M, Söhl G, Jahnke K, Winterhager E, Herberhold C, Hardelin JP, Petit C, Willecke K. 2003. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum Mol Genet 12: 1321.
  • Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. 2008. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med 14: 681687.
  • Turner NA, Xia F, Azhar G, Zhang X, Liu L, Wei JY. 1998. Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells. J Mol Cell Cardiol 20: 17891801.
  • Usami SI, Moteki H, Suzuki N, Fukuoka H, Miyagawa M, Nishio SY, Takumi Y, Iwasaki S, Jolly C. 2011. Achievement of hearing preservation in the presence of an electrode covering the residual hearing region. Acta Otolaryngol 131: 405412.
  • van Bergen P, Rauhala P, Spooner CM, Chiueh CC. 1999. Hemoglobin and iron-evoked oxidative stress in the brain: protection by bile pigments, manganese, and S-nitrosoglutathione. Free Radic Res 31: 631640.
  • van de Water TR. Historical aspects of inner ear anatomy and biology that underlie the design of hearing and balance prosthetic devices. Anat Rec, in press.
  • van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, Gevaert K, van de Kerckove J, Declercq W, van de Nabeele P. 2002. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XiaP and induces enhanced caspase activity. Cell Death Diff 9: 2026.
  • van Wijk F, Staecker H, Keithley E, Lefebvre PP. 2006. Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol 11: 357365.
  • Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102: 4353.
  • Vivero RJ, Joseph DE, Angeli S, He J, Chen S, Eshraghi AA, Balkany TJ, van de Water TR. 2008. Dexamethasone base conserves hearing from electrode trauma-induced hearing loss. Laryngoscope 118: 20282035.
  • von Békésy G. 1952. Resting potential inside the cochlear partition of the guinea pig. Nature 169: 241242.
  • von Ilberg CA, Baumann U, Kiefer J, Tillein J, Adunka OF. 2011. Electric-acoustic stimulation of the auditory system: a review of the first decade. Audiol Neurootol 16: 130.
  • von Ilberg C, Kiefer J, Tillein J, Pfenningdorff T, Hartmann R, Stürzebecher E, Klinke R. 1999. Electric-acoustic stimulation of the auditory system. New technology for severe hearing loss. ORL J Otorhinolaryngol Relat Spec 61: 334340.
  • Wang J, van de Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A. 2003. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory HC death and hearing loss. J Neurosci 23: 85968607.
  • Wang X, Martindale JL, Liu Y, Holbrook NJ. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signaling pathways on cell survival. Biochem J 333: 291300.
  • Wangemann P, Itza EM, Albrecht B, Wu T, Jabba SV, Maganti RJ, Lee JH, Everett LA, Wall SM, Royaux IE, Green ED, Marcus DC. 2004. Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model. BMC Med 2: 3030.
  • Widlak P, Garrard WT. 2001. Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD. Mol Cell Biochem 218: 125130.
  • Widlak P, Li LY, Wang X, Garrard WT. 2001. Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I. J Biol Chem 276: 4840448409.
  • Wimmer C, Mees K, Stumpf P, Welsch U, Reichel O, Suckfüll M. 2004. Round window application of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 in cisplatin-induced ototoxicity. Otol Neurotol 25: 3340.
  • Woo CH, Eom YW, Yoo MH, You HJ, Han HJ, Song WK, Yoo YJ, Chun JS, Kim JH. 2000. Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade. J Biol Chem 275: 3235732362.
  • Wu G, Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y. 2000. Structural basis of IAP recognition by Smac/DIABLO. Nature 408: 10081012.
  • Yamane H, Nakai Y, Takayama M, Konishi K, Iguchi H, Nakagawa T, Shibata S, Kato A, Sunami K, Kawakatsu C. 1995. The emergence of free radicals after acoustic trauma and strial blood flow. Acta Otolaryngol (Suppl) 519: 8792.
  • Yamashita D, Miller JM, Jiang HY, Minami SB, Schacht J. 2004. AIF and EndoG in noise-induced hearing loss. Neuroreport 15: 27192722.
  • Ye Q, Tillein J, Hartmann R, Gstöettner W, Kiefer J. 2007. Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention. Ear Hear 28: 361369.
  • Yoshida K, Ichimiya I, Suzuki M, Mogi G. 1999. Effect of proinflammatory cytokines on cultured spiral ligament fibrocytes. Hear Res 137: 155159.
  • Zhuang S, Demirs JT, Kochevar IE. 2000. P38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J Biol Chem 275: 2593925948.
  • Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. 2004. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18: 12721282.
  • Zou J, Bretlau P, Pyykkö I, Starck J, Toppila E. 2001. Sensorineural hearing loss after vibration: an animal model for evaluating prevention and treatment of inner ear hearing loss. Acta Otolaryngol 121: 143148.
  • Zou J, Pyykkö I, Sutinen P, Toppila E. 2005. Vibration induced hearing loss in guinea pig cochlea: expression of TNF-α and VEGF. Hear Res 202: 1320.