Both authors contributed equally to this paper.
Immunohistochemical Detection of the Putative Mechanoproteins ASIC2 and TRPV4 in Avian Herbst Sensory Corpuscles
Article first published online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 296, Issue 1, pages 117–122, January 2013
How to Cite
Cabo, R., Gálvez, A., Laurà, R., San José, I., Pastor, J.F., López-Muñiz, A., García-Suárez, O. and Vega, J.A. (2013), Immunohistochemical Detection of the Putative Mechanoproteins ASIC2 and TRPV4 in Avian Herbst Sensory Corpuscles. Anat Rec, 296: 117–122. doi: 10.1002/ar.22615
- Issue published online: 15 DEC 2012
- Article first published online: 14 NOV 2012
- Manuscript Accepted: 29 JUL 2012
- Manuscript Revised: 6 JUL 2012
- Manuscript Received: 29 APR 2012
- cutaneous Herbst corpuscles;
- Columba livia
The avian Herbst corpuscles are the equivalent of the Pacinian corpuscles in mammals, and detect vibration and the movement of joints and feathers. Therefore, they can be regarded as rapidly adapting low-threshold mechanoreceptors. In recent years, it has been establish that some ion channels are involved in mechanosensation and are present in both mechanosensory neurons and mechanoreceptors. Here we have used immunohistochemistry to localize some putative mechanoproteins in the Herbst corpuscles from the rictus of Columba livia. The proteins investigated were the subunits of the epithelial Na+ channel (ENaC), the transient-receptor potential vanilloid 4 (TRPV4), and the acid-sensing ion channel 2 (ASIC2). Immunoreactivity for ENaC subunits was never found in Herbst corpuscles, while the axon expressed ASIC2 and TRPV4 immunoreactivity. Moreover, TRPV4 was also detected in the cell forming the inner core. The present results demonstrate for the first time the occurrence of mechanoproteins in avian low-threshold mechanoreceptors and provide further evidence for a possible role of the ion channels in mechanosensation. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.