D.L. and L.H. contributed equally to this work.
Somal and Dendritic Development of Human CA3 Pyramidal Neurons F rom Midgestation to Middle Childhood: A Quantitative Golgi Study
Version of Record online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 296, Issue 1, pages 123–132, January 2013
How to Cite
Lu, D., He, L., Xiang, W., Ai, W.-M., Cao, Y., Wang, X.-S., Pan, A., Luo, X.-G., Li, Z. and Yan, X.-X. (2013), Somal and Dendritic Development of Human CA3 Pyramidal Neurons F rom Midgestation to Middle Childhood: A Quantitative Golgi Study. Anat Rec, 296: 123–132. doi: 10.1002/ar.22616
- Issue online: 15 DEC 2012
- Version of Record online: 14 NOV 2012
- Manuscript Accepted: 18 SEP 2012
- Manuscript Revised: 5 AUG 2012
- Manuscript Received: 29 MAY 2012
- Central South University. Grant Number: Project 985
- National Natural Science Foundation of China. Grant Number: 81171160
- human hippocampus;
- CA3 area;
- pyramidal neurons;
The CA3 area serves a key relay on the tri-synaptic loop of the hippocampal formation which supports multiple forms of mnemonic processing, especially spatial learning and memory. To date, morphometric data about human CA3 pyramidal neurons are relatively rare, with little information available for their pre- and postnatal development. Herein, we report a set of developmental trajectory data, including somal growth, dendritic elongation and branching, and spine formation, of human CA3 pyramidal neurons from midgestation stage to middle childhood. Golgi-impregnated CA3 pyramidal neurons in fetuses at 19, 20, 26, 35, and 38 weeks of gestation (GW) and a child at 8 years of age (Y) were analyzed by Neurolucida morphometry. Somal size of the impregnated CA3 cells increased age-dependently among the cases. The length of the apical and basal dendrites of these neurons increased between 26 GW to 38 GW, and appeared to remain stable afterward until 8 Y. Dendritic branching points increased from 26 GW to 38 GW, with that on the apical dendrites slightly reduced at 8 Y. Spine density on the apical and basal dendrites increased progressively from 26 GW to 8 Y. These data suggest that somal growth and dendritic arborization of human CA3 pyramidal neurons occur largely during the second to third trimester. Spine development and likely synaptogenesis on CA3 pyramidal cells progress during the third prenatal trimester and may continue throughout childhood. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.