MT2-MMP Expression During Early Avian Morphogenesis
Article first published online: 15 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 296, Issue 1, pages 64–70, January 2013
How to Cite
Patterson, R. A., Cavanaugh, A. M., Cantemir, V., Brauer, P. R. and Reedy, M. V. (2013), MT2-MMP Expression During Early Avian Morphogenesis. Anat Rec, 296: 64–70. doi: 10.1002/ar.22618
- Issue published online: 15 DEC 2012
- Article first published online: 15 NOV 2012
- Manuscript Accepted: 20 SEP 2012
- Manuscript Received: 8 MAR 2012
- NIH. Grant Numbers: P20 RR016469 (NCCR), 8P20GM103427 (NIGMS)
- American Heart Association—Heartland Affiliate. Grant Number: 0555683Z
- chicken embryo;
Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.