Migration of Resident Cardiac Stem Cells in Myocardial Infarction
Article first published online: 5 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
The Anatomical Record
Volume 296, Issue 2, pages 184–191, February 2013
How to Cite
Liang, S. X. and Phillips, W. D. (2013), Migration of Resident Cardiac Stem Cells in Myocardial Infarction. Anat Rec, 296: 184–191. doi: 10.1002/ar.22633
- Issue published online: 25 JAN 2013
- Article first published online: 5 DEC 2012
- Manuscript Accepted: 20 OCT 2012
- Manuscript Received: 2 OCT 2011
- The Initial Assistance Fund for Medical Research, Liaoning Medical University, China. Grant Number: 2012LYRC02
- cardiac stem cells;
- myocardial infarction;
Ischemic heart disease is a major cause of morbidity and mortality worldwide. Stem cell-based therapy, which aims to restore cardiac structure and function by regeneration of functional myocardium, has recently been proposed as a novel alternative treatment modality. Resident cardiac stem cells (CSCs) in adult hearts are a key cell type under investigation. CSCs have been shown to be able to repair damaged myocardium and improve myocardial function in both human and animal studies. This approach relies not only on the proliferation of the CSCs, but also upon their migration to the site of injury within the heart. Here, we briefly review reported CSC populations and discuss signaling factors and pathways required for the migration of CSCs. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.