Integration of Autophagy and Anoikis Resistance in Solid Tumors

Authors

  • Jie Yang,

    1. Department of Biochemistry and Molecular Biology, Heping District, Tianjin, China
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  • Zhichao Zheng,

    1. Tianjin Research Center of Basic Medical Sciences, Tianjin Medical University, Heping District, Tianjin, China
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  • Xiaojie Yan,

    1. Department of Biochemistry and Molecular Biology, Heping District, Tianjin, China
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  • Xia Li,

    1. Department of Pharmaceutical Engineering, Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Nankai District, Tianjin, China
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  • Zhe Liu,

    Corresponding author
    1. Department of Immunology, School of Basic Medical Sciences, Heping District, Tianjin, China
    2. Tianjin Key Laboratory of Medical Epigenetics, Heping District, Tianjin, China
    3. 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Heping District, Tianjin, China
    • Tianjin Research Center of Basic Medical Sciences, Tianjin Medical University, Heping District, Tianjin, China
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  • Zhenyi Ma

    Corresponding author
    • Department of Biochemistry and Molecular Biology, Heping District, Tianjin, China
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Correspondence to: Zhe Liu, Department of Immunology, Tianjin Key Laboratory of Medical Epigenetics, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Research Center of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China. E-mail: zheliu@tmu.edu.cn or Zhenyi Ma, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China. Fax: 86-22-83336533. E-mail: zhyma@tmu.edu.cn

ABSTRACT

Macroautophagy or autophagy is a lysosome-dependent process in which enzymatic degradation and recycling of cytosolic components occurred due to stressful conditions. This cellular arrangement imparts anoikis resistance in solid tumors. Anoikis, a special form of apoptosis occurring when cells detach from the extracellular matrix, is a critical mechanism in maintaining tissue homeostasis and development. Anoikis resistance facilitates tumorigenesis and metastasis. However, the complexity of the role of autophagy in tumor is underscored by evidence that autophagy can function as both a pro-survival or pro-death depending on the context and the stimuli, which are likely exploitable for tumor therapy. This review focuses on recent progress in understanding anoikis resistance and autophagy signaling, paying particular attention to its relevance in solid tumor metastasis. Anat Rec, 296:1501–1508, 2013. © 2013 Wiley Periodicals, Inc.

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