F. de Carlos and J. Cobo contributed equally to this article.
The Sensory Innervation of the Human Pharynx: Searching for Mechanoreceptors
Article first published online: 4 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
The Anatomical Record
Volume 296, Issue 11, pages 1735–1746, November 2013
How to Cite
de Carlos, F., Cobo, J., Macías, E., Feito, J., Cobo, T., Calavia, M.G., García-Suárez, O. and Vega, J.A. (2013), The Sensory Innervation of the Human Pharynx: Searching for Mechanoreceptors. Anat Rec, 296: 1735–1746. doi: 10.1002/ar.22792
- Issue published online: 24 OCT 2013
- Article first published online: 4 OCT 2013
- Manuscript Received: 19 DEC 2013
- Manuscript Accepted: 16 JUL 2013
- Instituto Asturiano de Odontologia, Oviedo, Spain
- superior constrictor pharyngeal muscle;
The coordinate neural regulation of the upper airways muscles is basic to control airway size and resistance. The superior constrictor pharyngeal muscle (SCPM) forms the main part of the lateral and posterior walls of the pharynx and typically is devoid of muscle spindles, the main type of proprioceptor. Because proprioception arising from SCPM is potentially important in the physiology of the upper airways, we have investigated if there are mechanical sensory nerve endings substitute for the muscle spindles. Samples of human pharynx were analyzed using immunohistochemistry associated to general axonic and Schwann cells markers (NSE, PGP 9.5, RT-97, and S100P), intrafusal muscle fiber markers, and putative mechanical sense proteins (TRPV4 and ASIC2). Different kinds of sensory corpuscles were observed in the pharynx walls (Pacini-like corpuscles, Ruffini-like corpuscles, spiral-wharves nerve structures, and others) which are supplied by sensory nerves and express putative mechanoproteins. No evidence of muscle spindles was observed. The present results demonstrate the occurrence of numerous and different morphotypes of sensory corpuscles/mechanoreceptors in human pharynx that presumably detect mechanical changes in the upper airways and replace muscle spindles for proprioception. Present findings are of potential interest for the knowledge of pathologies of the upper airways with supposed sensory pathogenesis. Anat Rec, 296:1735–1746, 2013. © 2013 Wiley Periodicals, Inc.