Kurt H. Albertine*
A New Age of Regenerative Medicine: Fusion of Tissue Engineering and Stem Cell Research
Version of Record online: 2 DEC 2013
Copyright © 2013 Wiley Periodicals, Inc.
The Anatomical Record
Special Issue: A New Age of Regenerative Medicine: Fusion of Tissue Engineering and Stem Cell Research
Volume 297, Issue 1, pages 1–3, January 2014
How to Cite
Albertine, K. H. and Dezawa, M. (2014), A New Age of Regenerative Medicine: Fusion of Tissue Engineering and Stem Cell Research. Anat Rec, 297: 1–3. doi: 10.1002/ar.22811
- Issue online: 16 DEC 2013
- Version of Record online: 2 DEC 2013
- Manuscript Received: 16 SEP 2013
- Manuscript Accepted: 16 SEP 2013
An exciting era is on our doorstep: regenerative medicine. Why? Because knowledge and technology are converging to the point where cell or tissue therapies are becoming more and more available, world-wide. Another reason is because regenerative medicine relies on interdisciplinary, team-science that brings basic scientists and clinicians together. This union, which is consistent with the Journal's emphasis of integrative biology that crosses disciplines, appears to be a paradigm for science of the future. For these reasons, The Anatomical Record is proud to publish this special issue on stem cells and tissue engineering.
Another reason for the Journal's pride is its substantial archive of published papers that are related to regenerative medicine. Perusing the archive reveals nearly 100 papers on stem cells and/or tissue engineering. One of the first papers characterizes spermatogonia stem-cell renewal in the mouse (Oakberg, 1971). More than a decade later, a paper describes myosatellite cell growth and regeneration in a mouse model of dystrophic muscle (Ontell et al., 1984). The number of regenerative medicine-related papers during the decade of the 1990s equals the number such papers published in the preceding two decades. The two papers focus on guided tissue regeneration related to endosseous dental implants (Listgarten, 1996) and pluripotent embryonic stem cell models of development (O'Shea, 1999).
The number of publications in The Anatomical Record that are related to regenerative medicine exploded in the 21st century. One paper, which reported temporary airway epithelial repopulation and rare clonal formation by mesenchymal stem cells after injury to the lung of mice (Serikov et al., 2007), provided the cover illustration for the Journal (Volume 290, 2007). Nearly 20 papers reported results for the cardiovascular system, including the heart (Eisenberg and Eisenberg, 2004; Rosen et al., 2004; Perez-Pomares et al., 2006). Also well represented is the nervous system (ca. 15 papers) (Geuna et al., 2001; Gokhan and Mehler, 2001; Zhang et al., 2010). So are bone (ca. 10 papers) (Mishra and Knothe Tate, 2003; Umehara et al., 2012) and cartilage (also ca. 10 papers) (Huang et al., 2004; Mauck et al., 2007). Other papers report results for cellular motors for manufacturing molecules (Dinu et al., 2007), matrices (Badylak, 2005), adipose tissue (Patrick, 2001), hematology (Yoder, 2004), cochlear and vestibular systems (Eshraghi et al., 2012; Fridman and Della Santina, 2012), germ lines (Oakberg, 1971), muscle (Hirschi and Majesky, 2004), skin (Casasco et al., 2001), reserve stem cells (Young et al., 2001), embryonic stem cells (Gokhan and Mehler, 2001), wound healing (Delorme et al., 2012), methods (An et al., 2001; Merzkirch et al., 2001; Liu et al., 2012), in vivo tracking (Cao et al., 2009), and tissue engineering (Evans, 2001; Gutowska et al., 2001; Mann and West, 2001; Walgenbach et al., 2001; Boland et al., 2003). Lastly, a number of reviews on stem cells, tissue engineering, and regenerative medicine are among the legion of papers that are published in The Anatomical Record (Carlson, 1999; Mironov and Markwald, 2001; Young and Black, 2004; Di Felice et al., 2009; Hong et al., 2010). You are invited to access and read these important papers (http://onlinelibrary.wiley.com/journal/10.1002/%28 ISSN%291932-8494).
A motivation for the present special issue on stem cells and tissue engineering is that injury or disease creates defects that represent challenges to surgical reconstruction or replacement to improve quality of life or life expectancy. The papers in this special issue provide contemporary assessments of the emerging fields of stem cells and tissue engineering, an important goal of which is to help develop biological substitutes that restore structure and function. Along the way, the papers consider essential principals and methods that underlie successful applications of stem cells and tissue engineering. These considerations are important because of the need to optimize techniques to acquire and expand cells and tissues, and provide scaffolds to shape tissues and organs. Equally importantly, in vivo testing in large animal models is necessary to determine efficacy, durability, and safety because the target is treatment of human subjects with injury or disease. We hope that the papers in this special issue will stimulate readers to continue to push the fields of stem cells and tissue engineering to expand translation to human applications of regenerative medicine (Mitrecic et al., 2009).
Editor-in-Chief, The Anatomical Record
Division of Neonatology
Department of Pediatrics
University of Utah
Salt Lake City, Utah
Associate Editor, The Anatomical Record
Department of Stem Cell Biology and Histology
Tohoku University Graduate School of Medicine
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- 2005. Regenerative medicine and developmental biology: the role of the extracellular matrix. Anat Rec B New Anat 287:36–41. .
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- 2009. In vivo tracking of dual-labeled mesenchymal stem cells homing into the injured common carotid artery. Anat Rec (Hoboken) 292:1677–1683. , , , .
- 1999. Stem cells and cloning: what's the difference and why the fuss? Anat Rec 257:1–2. .
- 2001. Cell proliferation and differentiation in a model of human skin equivalent. Anat Rec 264:261–272. , , , , .
- 2012. Scar-free wound healing and regeneration following tail loss in the leopard gecko, Eublepharis macularius. Anat Rec (Hoboken) 295:1575–1595. , , .
- 2009. Cardiac stem cell research: an elephant in the room? Anat Rec (Hoboken) 292:449–454. , , , , , , , , .
- 2007. Cellular motors for molecular manufacturing. Anat Rec (Hoboken) 290:1203–1212. , , , .
- 2004. Adult stem cells and their cardiac potential. Anat Rec A Discov Mol Cell Evol Biol 276:103–112. , .
- 2012. Biomedical engineering principles of modern cochlear implants and recent surgical innovations. Anat Rec (Hoboken) 295:1957–1966. , , , , , .
- 2001. Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec 263:396–404. .
- 2012. Progress toward development of a multichannel vestibular prosthesis for treatment of bilateral vestibular deficiency. Anat Rec (Hoboken) 295:2010–2029. , .
- 2001. Adult stem cells and neurogenesis: historical roots and state of the art. Anat Rec 265:132–141. , , , .
- 2001. Basic and clinical neuroscience applications of embryonic stem cells. Anat Rec 265:142–156. , .
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- 2004. Smooth muscle stem cells. Anat Rec A Discov Mol Cell Evol Biol 276:22–33. , .
- 2010. Genetically engineered mesenchymal stem cells: the ongoing research for bone tissue engineering. Anat Rec (Hoboken) 293:531–537. , , , .
- 2004. Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture. Anat Rec A Discov Mol Cell Evol Biol 278:428–436. , , , , .
- 1996. Soft and hard tissue response to endosseous dental implants. Anat Rec 245:410–425. .
- 2012. Conditioned medium from chondrocyte/scaffold constructs induced chondrogenic differentiation of bone marrow stromal cells. Anat Rec (Hoboken) 295:1109–1116. , , , , .
- 2001. Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. Anat Rec 263:367–371. , .
- 2007. Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Anat Rec (Hoboken) 290:48–58. , , , .
- 2001. Engineering of vascular ingrowth matrices: are protein domains an alternative to peptides? Anat Rec 263:379–387. , , .
- 2001. Anatomy of tissue engineering. Anat Rec 263:335. , .
- 2003. Effect of lacunocanalicular architecture on hydraulic conductance in bone tissue: implications for bone health and evolution. Anat Rec A Discov Mol Cell Evol Biol 273:752–762. , .
- 2009. Toward the treatments with neural stem cells: experiences from amyotrophic lateral sclerosis. Anat Rec (Hoboken) 292:1962–1967. , , .
- 1999. Embryonic stem cell models of development. Anat Rec 257:32–41. .
- 1971. Spermatogonial stem-cell renewal in the mouse. Anat Rec 169:515–531. .
- 1984. Myosatellite cells, growth, and regeneration in murine dystrophic muscle: a quantitative study. Anat Rec 208:159–174. , , , , .
- 2001. Tissue engineering strategies for adipose tissue repair. Anat Rec 263:361–366. .
- 2006. In vitro self-assembly of proepicardial cell aggregates: an embryonic vasculogenic model for vascular tissue engineering. Anat Rec A Discov Mol Cell Evol Biol 288:700–713. , , , , , .
- 2004. Recreating the biological pacemaker. Anat Rec A Discov Mol Cell Evol Biol 280:1046–1052. , , , .
- 2007. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken) 290:1033–1045. , , , , .
- 2012. Canine oral mucosal fibroblasts differentiate into osteoblastic cells in response to BMP-2. Anat Rec (Hoboken) 295:1327–1335. , , , , , , .
- 2001. Tissue engineering in plastic reconstructive surgery. Anat Rec 263:372–378. , , , , , , .
- 2004. Blood cell progenitors: insights into the properties of stem cells. Anat Rec A Discov Mol Cell Evol Biol 276:66–74. .
- 2004. Adult stem cells. Anat Rec A Discov Mol Cell Evol Biol 276:75–102. , .
- 2001. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec 264:51–62. , , , , , , , , , , , ,
- 2010. Stem cells: current approach and future prospects in spinal cord injury repair. Anat Rec (Hoboken) 293:519–530. , , , .