Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness
Article first published online: 25 JUN 2014
© 2014 Wiley Periodicals, Inc.
The Anatomical Record
Volume 297, Issue 10, pages 1817–1828, October 2014
How to Cite
Goldman, H. M., Hampson, N. A., Guth, J. J., Lin, D. and Jepsen, K. J. (2014), Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness. Anat Rec, 297: 1817–1828. doi: 10.1002/ar.22962
- Issue published online: 16 SEP 2014
- Article first published online: 25 JUN 2014
- Manuscript Accepted: 21 MAY 2014
- Manuscript Received: 5 FEB 2014
- US Department of Defense . Grant Number: (DoD) W81XWH-09-2-0113 and W81XWH-07-C-0097
- NIH . Grant Number: AR44927
- complex adaptive system;
- cortical bone;
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue-level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU-based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, P < 0.004], total osteon area [R2 = 0.42, P < 0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU-based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how interindividual variation in remodeling differentially impacts skeletal aging and an individuals' potential response to prophylactic treatments. Anat Rec, 297:1817–1828, 2014. © 2014 Wiley Periodicals, Inc.