Correlation of GDF5 and connexin 43 mRNA expression during embryonic development

Authors

  • Cynthia M. Coleman,

    1. Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    2. Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
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  • Grace A. Loredo,

    1. Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
    Current affiliation:
    1. Sacramento VA Medical Center, VA Northern California Health Care System, Mather, California
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  • Cecilia W. Lo,

    1. Biology Department, University of Pennsylvania, Philadelphia, Pennsylvania
    2. Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
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  • Rocky S. Tuan

    Corresponding author
    1. Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    2. Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
    • Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892
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    • Fax: (301) 402-2724


Abstract

Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis. Anat Rec Part A 275A:1117–1121, 2003. © 2003 Wiley-Liss, Inc.

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