Adult stem cells
Article first published online: 23 DEC 2003
Copyright © 2004 Wiley-Liss, Inc.
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Special Issue: Stem Cells and the Cardiovascular System
Volume 276A, Issue 1, pages 75–102, January 2004
How to Cite
Young, H. E. and Black, A. C. (2004), Adult stem cells. Anat. Rec., 276A: 75–102. doi: 10.1002/ar.a.10134
- Issue published online: 23 DEC 2003
- Article first published online: 23 DEC 2003
- Manuscript Accepted: 21 FEB 2003
- Manuscript Received: 27 JAN 2003
- Rubye Ryle Smith Charitable Trust
- MEDCEN Community Health Foundation
- MorphoGen Pharmaceuticals, Inc.
- stem cells;
Development of a multicellular organism is accomplished through a series of events that are preprogrammed in the genome. These events encompass cellular proliferation, lineage commitment, lineage progression, lineage expression, cellular inhibition, and regulated apoptosis. The sequential progression of cells through these events results in the formation of the differentiated cells, tissues, and organs that constitute an individual. Although most cells progress through this sequence during development, a few cells leave the developmental continuum to become reserve precursor cells. The reserve precursor cells are involved in the continual maintenance and repair of the tissues and organs throughout the life span of the individual. Until recently it was generally assumed that the precursor cells in postnatal individuals were limited to lineage-committed progenitor cells specific for various tissues. However, studies by Young, his colleagues, and others have demonstrated the presence of two categories of precursor cells that reside within the organs and tissues of postnatal animals. These two categories of precursor cells are lineage-committed (multipotent, tripotent, bipotent, and unipotent) progenitor cells and lineage-uncommitted pluripotent (epiblastic-like, ectodermal, mesodermal, and endodermal) stem cells. These reserve precursor cells provide for the continual maintenance and repair of the organism after birth. Anat Rec Part A 276A:75–102, 2004. © 2004 Wiley-Liss, Inc.