Reelin immunoreactivity in lymphatics and liver during development and adult life
Article first published online: 23 MAY 2005
Copyright © 2005 Wiley-Liss, Inc.
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume 285A, Issue 1, pages 595–599, July 2005
How to Cite
Samama, B. and Boehm, N. (2005), Reelin immunoreactivity in lymphatics and liver during development and adult life. Anat. Rec., 285A: 595–599. doi: 10.1002/ar.a.20202
- Issue published online: 21 JUN 2005
- Article first published online: 23 MAY 2005
- Manuscript Accepted: 24 FEB 2005
- Manuscript Received: 3 FEB 2004
- Conseil Scientifique de la Faculté de Médecine de Strasbourg
- Programme Hospitalier de Recherche Clinique 2002, Hôpitaux Universitaires de Strasbourg
Reelin, a glycoprotein secreted by Cajal-Retzius cells, is crucial for cortex lamination and cell positioning. Some peripheral reelin expression has also been reported. Here we describe in developing rat and human and in adult rat very definite reelin immunolocalization in two cell types. Reelin was present in endothelial cells of lymphatic vessels, but not of blood vessels. Reelin was also detected in stellate (Ito) cells of the liver as shown by immunoelectron microscopic examination. The immunlocalization observed in adult tissues indicates a broader role of reelin beyond its previously demonstrated role in neuronal development. © 2005 Wiley-Liss, Inc.