Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery
Article first published online: 21 NOV 2005
Copyright © 2005 Wiley-Liss, Inc.
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume 287A, Issue 2, pages 1165–1175, December 2005
How to Cite
Hidai, C., Kawana, M., Habu, K., Kazama, H., Kawase, Y., Iwata, T., Suzuki, H., Quertermous, T. and Kokubun, S. (2005), Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery. Anat. Rec., 287A: 1165–1175. doi: 10.1002/ar.a.20247
- Issue published online: 24 NOV 2005
- Article first published online: 21 NOV 2005
- Manuscript Accepted: 26 JUL 2005
- Manuscript Received: 29 MAR 2005
- Japanese Ministry of Education. Grant Number: 13670027
- branching morphogenesis;
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery. © 2005 Wiley-Liss, Inc.