SEARCH

SEARCH BY CITATION

Keywords:

  • branching morphogenesis;
  • angiogenesis;
  • mesentery;
  • Del1;
  • SDF-1

Abstract

In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery. © 2005 Wiley-Liss, Inc.