The first two authors contributed equally to this work.
Biological behavior of the gerbil ventral prostate in three phases of postnatal development
Article first published online: 15 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume 288A, Issue 7, pages 723–733, July 2006
How to Cite
Pegorin De Campos, S. G., Zanetoni, C., Góes, R. M. and Taboga, S. R. (2006), Biological behavior of the gerbil ventral prostate in three phases of postnatal development. Anat. Rec., 288A: 723–733. doi: 10.1002/ar.a.20347
- Issue published online: 26 JUN 2006
- Article first published online: 15 JUN 2006
- Manuscript Accepted: 23 MAR 2006
- Manuscript Received: 3 NOV 2005
- Brazilian National R&D Council (CNPq)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- São Paulo State Research Foundation (FAPESP)
- ventral prostate;
- proliferative lesions;
In this study, we characterized the gerbil's ventral prostate histology ultrastructurally and quantitatively throughout three phases of postnatal development (young, adult, and old) in order to comprehend its biological behavior and propensity to developing spontaneous lesions with aging. The gerbil prostate is composed of alveoli and ducts immersed in a stroma composed of smooth muscle, fibroblasts, collagen and elastic fibers and vessels. The prostate tissue components present morphological and quantitative aspects that vary according to age. Young animals have an immature gland with modest secretory activity. Synthetic activity remained stable in adult and old gerbil. However, prostatic morphology was altered in the aging, showing an increased epithelium and stromal fibrosis. The nuclei of the secretory cells increased with aging, whereas nucleoli presented few alterations during postnatal development. The epithelial proliferation and stromal remodeling noted in this study indicate that the gerbil prostate may respond to the androgen declines typical of senescence through epithelial proliferation and stromal remodeling. Anat Rec, Part A, 288A:723–733, 2006. © 2006 Wiley-Liss, Inc.