Wufu Zhu, Yajing Liu, Yanfang Zhao, Haiyan Wang, Li Tan, Weijie Fan and Ping Gong
A series of 6-hydrazinyl-2,4-bismorpholino pyrimidine and 1,3,5-triazine derivatives were synthesized and evaluated for their biological activity. The most promising compound 5j showed strong antiproliferative activity against H460, HT-29, and MDA-MB-231 cell lines with IC50 values of 0.05, 6.31, and 6.50 µM, which were 4.6- to 190.4-fold more active than reference compound 1, respectively. However, compound 5j exhibited weaker potency against mTOR than compound 1. Further studies on the mechanism of action are in progress.