Archiv der Pharmazie

Cover image for Vol. 347 Issue 1

January 2014

Volume 347, Issue 1

Pages 1–76

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Editorial Board
    5. Review Article
    6. Full Papers
    1. You have free access to this content
      Cover Picture: Arch. Pharm. Chem. Life Sci. (1/2014)

      Article first published online: 3 JAN 2014 | DOI: 10.1002/ardp.201470001

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Editorial Board
    5. Review Article
    6. Full Papers
    1. Contents: Arch. Pharm. Chem. Life Sci. (1/2014)

      Article first published online: 3 JAN 2014 | DOI: 10.1002/ardp.201470002

  3. Editorial Board

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Editorial Board
    5. Review Article
    6. Full Papers
    1. Editorial Board: Arch. Pharm. Chem. Life Sci. (1/2014)

      Article first published online: 3 JAN 2014 | DOI: 10.1002/ardp.201470003

  4. Review Article

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Editorial Board
    5. Review Article
    6. Full Papers
    1. Oxadiazoles as Privileged Motifs for Promising Anticancer Leads: Recent Advances and Future Prospects (pages 1–20)

      Imtiaz Khan, Aliya Ibrar and Naeem Abbas

      Article first published online: 22 NOV 2013 | DOI: 10.1002/ardp.201300231

      Thumbnail image of graphical abstract

      The search for biologically promising, new chemical entities against the deadly cancer disease remains an important theme in drug discovery. Although many drug molecules are already in use for the treatment of cancer, there are still a lot of challenges in the development of new drug candidates. This paper surveys the recent efforts undertaken for the identification, optimization, and development of potent anticancer agents.

  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Editorial Board
    5. Review Article
    6. Full Papers
    1. Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity (pages 21–31)

      Corinna Lueg, Fabian Galla, Bastian Frehland, Dirk Schepmann, Constantin G. Daniliuc, Winnie Deuther-Conrad, Peter Brust and Bernhard Wünsch

      Article first published online: 18 NOV 2013 | DOI: 10.1002/ardp.201300255

      Thumbnail image of graphical abstract

      Reaction of carbazole with cyclic sulfates allows the direct introduction of ω-hydroyalkyl moieties at the carbazole N-atom. The hydroxypropyl substituted propionamides (n = 2) show the best balance between polarity and high affinity towards the cannabinoid CB2 receptor.

    2. Synthesis and Evaluation of Novel 2,3-Dihydrobenzo[b][1,4]dioxin- and Indolealkylamine Derivatives as Potential Antidepressants (pages 32–41)

      Songlin Wang, Yin Chen, Xinghua Liu, Xiangqing Xu, Xin Liu, Bi-Feng Liu and Guisen Zhang

      Article first published online: 11 NOV 2013 | DOI: 10.1002/ardp.201300238

      Thumbnail image of graphical abstract

      A series of 3-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)ethyl-1H-indole derivatives were synthesized and the target compounds were evaluated for their antidepressant activities in vitro and in vivo. The compounds described were also evaluated for dual 5-HTT and 5-HT1A receptor activities.

    3. Lantabetulic Acid Derivatives Induce G1 Arrest and Apoptosis in Human Prostate Cancer Cells (pages 42–53)

      Kai-Wei Lin, Zih-You Lin, A-Mei Huang, Jing-Ru Weng, Ming-Hong Yen, Shyh-Chyun Yang and Chun-Nan Lin

      Article first published online: 18 NOV 2013 | DOI: 10.1002/ardp.201300224

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      Ten new lantabetulic acid (1) derivatives 211 were synthesized and evaluated for their cytotoxic activities against human prostate cancer cells (PC3). Compound 8 led to G1 phase arrest (10 μM) as well as to apoptosis induction (20 μM). The dual action of 8 could provide a new approach for the development of chemotherapeutic drugs.

    4. Synthesis and Antioxidant Activity of Bis and Tris Heterocycles (pages 54–67)

      Nabhubygari Mahaboob Basha, Dandu Seenaiah, Adivireddy Padmaja, Venkatapuram Padmavathi, Desaraju Suresh Bhargav and Tartte Vijaya

      Article first published online: 11 NOV 2013 | DOI: 10.1002/ardp.201300290

      Thumbnail image of graphical abstract

      A variety of bis heterocycles and tris heterocycles were prepared and screened for their antioxidant activities. Compound 5b displayed radical scavenging activity greater than the standard ascorbic acid whereas compounds 8b and 14b showed activities equal to ascorbic acid.

    5. Novel Sulphamides and Sulphonamides Incorporating the Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors (pages 68–76)

      Akın Akıncıoğlu, Meryem Topal, İlhami Gülçin and Süleyman Göksu

      Article first published online: 18 NOV 2013 | DOI: 10.1002/ardp.201300273

      Thumbnail image of graphical abstract

      New sulphamides and sulphonamides incorporating the tetralin scaffold were synthesized and tested for their acetylcholine esterase (AChE) and carbonic anhydrase (CA) inhibitory effects. The tested CA isoenzymes were inhibited in the low micromolar or sub-micromolar range. Sulphamides 1113 and sulphonamides 1416 showed moderate inhibition capacity towards AChE.

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