• 1
    Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988; 140: 2197200.
  • 2
    Richardson B, Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S. N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide. Arthritis Rheum 1988; 31: 9959.
  • 3
    Richardson B. Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells. Hum Immunol 1986; 17: 45670.
  • 4
    Richardson BC, Powers D, Hooper F, Yung RL, O'Rourke K. Lymphocyte function–associated antigen 1 overexpression and T cell autoreactivity. Arthritis Rheum 1994; 37: 136372.
  • 5
    Yung RL, Chang S, Hemati N, Johnson K, Richardson BC. Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo. Arthritis Rheum 1997; 40: 143643.
  • 6
    Quddus J, Johnson KJ, Gavalchin J, Amento EP, Chrisp CE, Yung RL, et al. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to induce a lupus-like disease in syngeneic mice. J Clin Invest 1993; 92: 3853.
  • 7
    Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC. Mechanisms of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 1995; 154: 302535.
  • 8
    Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, et al. Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest 1996; 97: 286671.
  • 9
    Richardson BC, Strahler JR, Pivirotto TS, Quddus J, Bayliss GE, Gross LA, et al. Phenotypic and functional similarities between 5-azacytidine–treated T cells and a T cell subset in patients with active systemic lupus erythematosus. Arthritis Rheum 1992; 35: 64762.
  • 10
    Takeuchi T, Amano K, Sekine H, Koide J, Abe T. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest 1993; 92: 300816.
  • 11
    Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990; 33: 166573.
  • 12
    Cornwell RD, Gollahon KA, Hickstein DD. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. Proc Natl Acad Sci U S A 1993; 90: 42215.
  • 13
    Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 12717.
  • 14
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 31524.
  • 15
    Bombardier C, Gladmann DD, Urowitz MB, Caron D, Chang CH, and the Committee on Prognosis Studies in SLE. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 1992; 35: 63040.
  • 16
    Clark SJ, Harrison J, Paul CL, Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res 1994; 22: 29907.
  • 17
    Deng C, Kaplan MJ, Yang J, Ray D, Zhang Z, McCune WJ, et al. Decreased ras–mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 2001; 44: 397407.
  • 18
    Brasier AR, Fortin JJ. Nonisotopic assays for reporter gene activity. In: AusubelFM, BrentR, KingstonRE, MooreDD, SeidmanJG, SmithJA, et al, editors. Current protocols in molecular biology. Suppl 29. New York: John Wiley & Sons; 2001. pp. 21224.
  • 19
    Yung R, Ray D, Eisenbraun JK, Deng C, Attwood J, Eisenbraun MD, et al. Unexpected effects of a heterozygous Dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity. J Gerontol Biol Sci 2001; 56: B268B276.
  • 20
    Nueda A, Lopez-Cabrea M, Vara A, Corbi AL. Characterization of the CD11a (Lα, LFA-1α) integrin gene promoter. J Biol Chem 1993; 268: 1930511.
  • 21
    Schmid CW, Rubin CM. Alu: what's the use? In: MaraiaRJ, editor. The impact of short interspersed elements (SINEs) on the host genome. Austin (TX): R.G. Landes; 1995. pp. 10523.
  • 22
    Bird A, Wolffe A. Methylation-induced repression: belts, braces, and chromatin. Cell 1999; 99: 4514.
  • 23
    Yang J, Deng C, Hemati N, Hanash SM, Richardson BC. Effect of mitogenic stimulation and DNA methylation on human T-cell DNA methyltransferase expression and activity. J Immunol 1997; 159: 13039.
  • 24
    Golbus J, Palella TD, Richardson BC. Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol 1990; 20: 186972.
  • 25
    Mohan C, Adams S, Stanik V, Datta SK. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 1993; 177: 136781.
  • 26
    Kohem CL, Brezinschek RI, Wisbey H, Tortorells C, Lipsky PE, Oppenheimer-Marks N. Enrichment of differentiated CD45Rbdim,CD27 − memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 1996; 39: 84454.
  • 27
    Dayal AK, Kammer GM. The T cell enigma in lupus. Arthritis Rheum 1996; 39: 2333.
  • 28
    Grolleau A, Kaplan MJ, Hanash SM, Beretta L, Richardson B. Increased expression of protein kinase PKR and inhibition of translation in T cells from lupus patients. J Clin Invest 2000; 106: 15618.
  • 29
    Desai-Mehta A, Mao C, Rajagopalan S, Robinson T, Datta SK. Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J Clin Invest 1995; 95: 53141.
  • 30
    Crow MK. Mechanisms of T-helper cell activation and function in systemic lupus erythematosus. In: KammerGM, TsokosGC, editors. Lupus: molecular and cellular pathogenesis. Totowa, NJ: The Humana Press; 1999. pp. 23156.
  • 31
    Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, et al. Human memory T lymphocytes express increased levels of three adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol 1988; 140: 14017.
  • 32
    Pallis M, Robins A, Powell R. Quantitative analysis of lymphocyte CD11a using standardized flow cytometry. Scand J Immunol 1993; 38: 55964.
  • 33
    Richardson B, Epstein WV. Utility of the fluorescent antinuclear antibody test in a single patient. Ann Intern Med 1981; 95: 3338.