Dr. Hsia's work was supported by a Physician Scientist Development Award from the Arthritis Foundation.
Original Article
You have full text access to this OnlineOpen article
Cost-effectiveness analysis of the Lyme disease vaccine
Article first published online: 6 JUN 2002
DOI: 10.1002/art.10270
Copyright © 2002 by the American College of Rheumatology
Additional Information
How to Cite
Hsia, E. C., Chung, J. B., Schwartz, J. S. and Albert, D. A. (2002), Cost-effectiveness analysis of the Lyme disease vaccine. Arthritis & Rheumatism, 46: 1651–1660. doi: 10.1002/art.10270
Publication History
- Issue published online: 6 JUN 2002
- Article first published online: 6 JUN 2002
- Manuscript Accepted: 25 JAN 2002
- Manuscript Received: 26 MAR 2001
REFERENCES
- 1
- 2
- 3Centers for Disease Control and Prevention. Lyme disease—United States, 1996. MMWR Morb Mortal Wkly Rep 1997; 46: 531–5.
- 4. Lyme disease vaccines [editorial]. Ann Intern Med 1998; 129: 583–5.
- 5. Vaccination as a modality to prevent Lyme disease: a status report. Infect Dis Clin North Am 1999; 13: 135–48.
- 6, , , , , , et al, the Lyme Disease Vaccine Study Group. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N Engl J Med 1998; 339: 209–15.
- 7
- 8, , , , . Evaluation of reactogenicity and immunogenicity of booster doses of LYMErixTM, recombinant L-Osp-A vaccine against Lyme disease (LD). Presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy; 1999 Sep; San Francisco (CA).
- 9, , , , , , et al, the Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease [published erratum appears in N Engl J Med 1998;339:571]. N Engl J Med 1998; 339: 216–22.
- 10, , . A cost-of-illness study of Lyme disease in the United States. Clin Ther 1998; 20: 993–1008.
- 11, , , . Prevention of Lyme disease after tick bites: a cost-effectiveness analysis. N Engl J Med 1992; 327: 534–41.
- 12Centers for Disease Control and Prevention. Summary of notifiable diseases, United States, 1998. MMWR Morb Mortal Wkly Rep 1998; 47:x, 46.
- 13, , , , , , et al. Test-treatment strategies for patients suspected of having Lyme disease: a cost-effectiveness analysis. Ann Intern Med 1998; 128: 37–48.
- 14Centers for Disease Control and Prevention. Recommendations for the use of Lyme disease vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1999; 48(RR-7): 1–17, 21–5.
- 15, . The Lyme disease vaccine: conception, development, and implementation. Ann Intern Med 2000; 132: 661–8.
- 16, , , , , , et al, the Infectious Diseases Society of America. Practice guidelines for the treatment of Lyme disease. Clin Infect Dis 2000; 31 Suppl 1: S1–14.
- 17
- 18CardinaleV, editor. Drug topics red book. Montvale (NJ): Medical Economics Company; 1999.
- 19, , , , , , et al. Empiric parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease: a cost-effectiveness analysis. Ann Intern Med 1993; 119: 503–9.
- 20US Bureau of Labor Statistics Web site. Consumer price indexes. Washington (DC): US Bureau of Labor Statistics; 2000. Accessed Sep. 14, 2000. URL: http://stats.bls.gov/cpihome.htm.
- 21, , , , . Rapid emergence of a focal epidemic of Lyme disease in coastal Massachusetts. N Engl J Med 1989; 320: 133–7.
- 22Lyme disease statistics 1992–1998 [computer file]. Centers for Disease Control and Prevention; 1999.
- 23, , , , . Occupation risk of Lyme disease in endemic areas of New York state. Ann N Y Acad Sci 1988; 539: 289–301.Direct Link:
- 24, . Lyme disease in outdoor workers: risk factors, preventive measures, and tick removal methods. Am J Epidemiol 1990; 131: 877–85.
- 25, , , , , , et al. Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease. Ann Intern Med 1999; 131: 919–26.
- 26, , , , . Long-term outcomes of persons with Lyme disease. JAMA 2000; 283: 609–16.
- 27, , , , , , et al. Predisposing factors for individuals' Lyme disease prevention practices: Connecticut, Maine, and Montana. Am J Public Health 1997; 87: 2035–8.
- 28, , , , , , et al. The geographic spread and temporal increase of the Lyme disease epidemic. JAMA 1991; 226: 1230–6.
- 29, , , , . Temporal correlations between tick abundance and prevalence of ticks infected with Borrelia burgdorferi and increasing incidence of Lyme disease. J Clin Microbiol 1998; 36: 1240–4.
- 30, , , , , . Estimation of the incidence of Lyme disease. Am J Epidemiol 1998; 148: 1018–26.
- 31. Prevention of Lyme disease: a review of the evidence. Mayo Clin Proc 2001; 76: 713–24.
- 32, , , , , , et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001; 345: 79–84.
- 33, , , , . The cost-effectiveness of vaccination against Lyme disease. Arch Intern Med 2001; 161: 554–61.
- 34, , . Vaccines for the 21st century: a tool for decision making. Washington (DC): National Academy Press; 1999.
- 35, , . The cost effectiveness of vaccinating against Lyme disease. Emerg Infect Dis 1999; 5: 321–8.
- 36, , . The cost-effectiveness of misoprostol in preventing serious gastrointestinal events associated with the use of nonsteroidal antiinflammatory drugs. Arthritis Rheum 1998; 41: 16–25.Direct Link:
- 37, , , , . Cost-effectiveness of infective endocarditis prophylaxis for mitral valve prolapse with or without a mitral regurgitant murmur. Am J Cardiol 1994; 74: 1024–9.
- 38, , , , , , et al. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 1998; 281: 703–6.
- 39. Patients sue over effects of vaccine. Philadelphia Inquirer. 2000 Jun 13;1, 10.
- 40Food and Drug Administration. Vaccine adverse event reporting system: report for Lymerix manufactured by SmithKline Beecham. Rockville (MD): Food and Drug Administration; 2000. p. 1–51.
- 41, , , , , . Lyme vaccine safety data reported to the vaccine adverse event reporting system (VAERS) of the USA from the first year of use [abstract]. Pharmacoepidemiol Drug Safety 2000; 9 Suppl 1: S61–2.
- 42. Anxiety and persistence of Lyme disease. Am J Med 1995; 98 Suppl 4A: 74S–78S.
- 43. The Lyme disease controversy: social and financial costs of misdiagnosis and mismanagement. Arch Intern Med 1996; 156: 1493–500.
- 44, , , , . The consequences of overdiagnosis and overtreatment of Lyme disease: an observational study. Ann Intern Med 1998; 128: 354–62.
- 45, , , , , . The public health impact of Lyme disease in Maryland. J Infect Dis 1996; 173: 1260–2.
- 46, , . Tick bites and Lyme disease in an endemic setting: problematic use of serologic testing and prophylactic antibiotic therapy. JAMA 1998; 279: 206–10.

1529-0131/asset/olbannerleft.gif?v=1&s=897b81612b4ad6cae003112184adc709261d5f61)
1529-0131/asset/olbannerright.gif?v=1&s=04654f5ea3cbb01656383e0c0d04b16fd0a9a896)
1529-0131/asset/cover.gif?v=1&s=104d5c2bb8ef72deba26790b855af7ab80697a0e)