• 1
    Kempson GE. Mechanical properties of articular cartilage. In: FreemanMAR, editor. Adult articular cartilage. 2nd ed. Turnbridge Wells (UK): Pitman Medical; 1979. p. 333414.
  • 2
    Akizuki S, Mow VC, Muller F, Pita JC, Howell DS. Tensile properties of human knee joint cartilage. I. Influence of ionic conditions, weight bearing, and fibrillation on tensile modulus. J Orthop Res 1986; 4: 37992.
  • 3
    Hollander AP, Heathfield TF, Webber C, Iwata Y, Rorabeck C, Bourne R, et al. Increased damage to type II collagen in osteoarthritic cartilage detected by a new immunoassay. J Clin Invest 1994; 93: 172232.
  • 4
    Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997; 99: 153445.
  • 5
    Kempson GE, Muir H, Pollard C, Tuke M. The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. Biochem Biophys Acta 1973; 297: 46572.
  • 6
    Akizuki S, Mow VC, Muller F, Pita JC, Howell DS. Tensile properties of human knee joint cartilage. II. Correlations between weight bearing and tissue pathology and the kinetics of swelling. J Orthop Res 1987; 5: 17386.
  • 7
    Dahlberg L, Billinghurst C, Manner P, Ionescu M, Reiner A, Tanzer M, et al. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1). Arthritis Rheum 2000; 43: 67382.
  • 8
    Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, et al. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum 2000; 43: 66472.
  • 9
    Neuhold LA, Killar L, Zhao W, Sung ML, Warner A, Kulik L, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001; 107: 3544.
  • 10
    Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 1995; 96: 285969.
  • 11
    Poole AR, Alini M, Hollander AP. Cellular biology of cartilage degradation. In: HendersonB, EdwardsJCW, PettipherER, editors. Mechanisms and models in rheumatoid arthritis. London: Academic Press; 1995. p. 163204.
  • 12
    Poole AR. Cartilage in health and disease. In: KoopmanWJ, editor. Arthritis and allied conditions. 14th ed. Philadelphia (PA): Lippincott, Williams & Wilkins; 2001. p. 22684.
  • 13
    Poole AR, Howell DS. Etiopathogenesis of osteoarthritis. In: MoskowitzRW, HowellDS, AltmanRD, BuckwalterJA, GoldbergVM, editors. Osteoarthritis diagnosis and management. 3rd ed. Philadelphia (PA): WB Saunders; 2001. p. 2947.
  • 14
    Moldovan F, Pelletier JP, Hambor J, Cloutier JM, Martel-Pelletier J. Collagenase-3 (matrix metalloproteinase 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor β. Arthritis Rheum 1997; 40: 165361.
  • 15
    Stoop R, Buma P, van der Kraan PM, Hollander AP, Billinghurst RC, Poole AR, et al. Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection. Arthritis Rheum 2000; 43: 212131.
  • 16
    Stoop R, van der Kraan PM, Buma P, Hollander AP, Billinghurst RC, Poole AR, et al. Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice. Arthritis Rheum 1999; 42: 23819.
  • 17
    Huebner JL, Otterness IG, Freund EM, Caterson B, Kraus VB. Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. Arthritis Rheum 1998; 41: 87790.
  • 18
    Altman R, Asch E, Block D, Bole G, Borenstein D, Brandt K, et al, and the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 103949.
  • 19
    Wu CW, Tchetina EV, Mwale F, Hasty K, Pidoux I, Reiner A, et al. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. J Bone Miner Res 2002; 17: 63951.