A randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: A preliminary report
Article first published online: 5 JUN 2002
Copyright © 2002 by the American College of Rheumatology
Arthritis Care & Research
Volume 47, Issue 3, pages 280–284, 15 June 2002
How to Cite
Das, S. K., Ramakrishnan, S., Mishra, K., Srivastava, R., Agarwal, G. G., Singh, R. and Sircar, A. R. (2002), A randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: A preliminary report. Arthritis & Rheumatism, 47: 280–284. doi: 10.1002/art.10455
- Issue published online: 5 JUN 2002
- Article first published online: 5 JUN 2002
- Manuscript Accepted: 21 AUG 2001
- Manuscript Received: 9 MAY 2001
- Indian Council of Medical Research, New Delhi, India
- Knee osteoarthritis
To determine if colchicine added to nimesulide may have a beneficial effect on osteoarthritis (OA) of the knee.
Colchicine 0.5 mg twice daily or placebo was added to nimesulide (a nonsteroidal antiinflammatory drug) in 36 patients with OA of the knee in a randomized, double-blind, placebo-controlled trial over a 5-month period.
The 30% improvement rate at 20 weeks was higher in the colchicine group than in the control group receiving placebo, as measured by total Western Ontario and McMaster University Osteoarthritis scores (57.9% versus 23.5%) and visual analog scale for index knee pain (52.6% versus 17.6%) (primary measures of response). The significance persisted on combined analysis by Mantel-Haenszel test (P = 0.062). Comparison of means also showed significant improvement in the colchicine group versus the control group in a multivariate analysis performed using T2 test (P = 0.0115).
Among patients with OA of the knee, the group receiving colchicine plus nimesulide exhibited significantly greater symptomatic benefit at 20 weeks than did the control group receiving nimesulide plus placebo.