Infliximab in primary Sjögren's syndrome: One-year followup



This article is corrected by:

  1. Errata: Notice of retraction of two articles (“Infliximab in patients with primary Sjögren's syndrome: A pilot study” and “Infliximab in patients with primary Sjögren's syndrome: one-year followup”) Volume 65, Issue 3, 814, Article first published online: 18 March 2013



To evaluate the safety and efficacy of a maintenance regimen of infliximab in patients with active primary Sjögren's syndrome (SS) over a 1-year period.


This followup study included 10 of the 16 patients with primary SS who participated in a pilot study. Patients who continued to have symptoms received additional infusions of infliximab for 1 year.


All patients completed the 1-year followup for evaluation of efficacy. After 1 year, a statistically significant decrease in global and local disease manifestations was observed in all 10 patients. Treatment was generally well tolerated, with the main side effect being a mild, self-limited infusion reaction.


Sustained improvement of active primary SS may be possible with infliximab treatment.