• 1
    Tan EM. Autoantibodies to nuclear antigen (ANA): their immunobiology and medicine. Adv Immunol 1982; 33: 167240.
  • 2
    Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR. Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972; 52: 14859.
  • 3
    Sharp GC, Alspaugh MA. Autoantibodies to nonhistone nuclear antigens. In: GuptaS, TalalN, editors. Immunology of rheumatic diseases. New York: Plenum Press; 1985. p. 197219.
  • 4
    Tan EM, Kunkel HG. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 1966; 96: 46471.
  • 5
    Bringmann P, Lührmann R. Purification of the individual snRNPs U1, U2, U5 and U4/U6 from HeLa cells and characterization of their protein constituents. EMBO J 1986; 13: 350916.
  • 6
    Pettersson I, Hinterberger M, Mimori T, Gottlieb E, Steiz JA. The structure of mammalian small nuclear ribonucleoproteins: identification of multiple protein components reactive with anti-(U1) ribonucleoprotein and anti-Sm autoantibodies. J Biol Chem 1984; 259: 590714.
  • 7
    Habets WJ, Berden JHM, Hoch SO, vanVenrooij WJ. Further characterization and subcellular localization of Sm and U1 ribonucleoprotein antigens. Eur J Immunol 1985; 15: 9927.
  • 8
    Van Venrooij WJ. Autoantibodies against small nuclear ribonucleoprotein components. J Rheumatol 1987; 14 Suppl 13: 7882.
  • 9
    Takeda Y, Wang GS, Wang RJ, Anderson SK, Pettersson I, Amaki S, et al. Enzyme-linked immunosorbent assay using (U) small nuclear ribonucleoprotein polypeptides as antigens to investigate the clinical significance of autoantibodies to these polypeptides. Clin Immunol Immunopathol 1989; 50: 21330.
  • 10
    Asano T, Takasaki Y. Clinical significance and evaluation of MESACUP RNP, Sm, SS-A and SS-B kit. J Med Pharm Sci 1993; 29: 76573.
  • 11
    Surowy CS, Santen VL, Scheib-Wixted SM, Spritz RA. Direct, sequence-specific binding of human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA. Mol Cell Biol 1989; 9: 417986.
  • 12
    Lutz-Freyermuth C, Query CC, Keene JD. Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. Proc Natl Acad Sci U S A 1990; 87: 63937.
  • 13
    Nelissen RLH, Heinrichs V, Habets WJ, Simons F, Lührmann R, van Venrooij WJ. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res 1991; 19: 44954.
  • 14
    Nelissen RLH, Will CL, van Venrooij WJ, Lührmann R. The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. EMBO J 1994; 13: 411325.
  • 15
    Wilusz J, Keene JD. Autoantibodies specific for U1 RNA and initiator methionine tRNA. J Biol Chem 1986; 261: 546772.
  • 16
    Deutscher SL, Keene JD. A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. Proc Natl Acad Sci U S A 1988; 85: 3299303.
  • 17
    Van Venrooij WJ, Hoet R, Castrop J, Hageman B, Mattaj IW, van de Putte LB. Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J Clin Invest 1990; 86: 215460.
  • 18
    Kasukawa R, Tojo T, Miyawaki S, Yoshida H, Tanimoto K, Nobunaga M, et al: Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: KasukawaR, SharpGC, editors. Mixed connective tissue disease and antinuclear antibodies. Amsterdam: Excerpta Medica; 1987. p. 417.
  • 19
    Forman MS, Nakamura M, Mimori T, Gelpi C, Hardin JA. Detection of antibodies to small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins using unlabeled cell extracts. Arthritis Rheum 1985; 28: 135661.
  • 20
    Boire G, Lopez-Longo F-J, Lapointe S, Ménard H-A. Sera from patients with autoimmune disease recognize conformational determinants on the 60-kd Ro/SS-A protein. Arthritis Rheum 1991; 34: 72230.
  • 21
    Tsuzaka K, Fujii T, Akizuki M, Mimori T, Tojo T, Fujii H, et al. Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sjögren's syndrome. Arthritis Rheum 1994; 37: 8892.
  • 22
    Wolin SL, Steiz JA. The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNPs. Proc Natl Acad Sci U S A 1984; 81: 19962000.
  • 23
    Boire G, Graft J. Human Ro ribonucleoprotein particles: characterization of native structure and stable association with the La polypeptide. J Clin Invest 1990; 85: 118290.
  • 24
    Boulanger C, Chabot B, Menard HA, Boire B. Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clin Exp Immunol 1995; 99: 2936.