• 1
    Lequesne M, Brandt KB, Bellamy N, Moskowitz R, Menkes CJ, Pelletier JP, et al. Guidelines for testing slow acting drugs in osteoarthritis. J Rheumatol Suppl 1994; 41: 6573.
  • 2
    Altman R, Brandt KD, Hochberg M, Moskowitz R, Bellamy N, Bloch DA, et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations for a task force of the Osteoarthritis Research Society. Results from a workshop. Osteoarthritis Cartilage 1996; 4: 21743.
  • 3
    Bellamy N. Clinical trials design: structure modifying agents for osteoarthritis. Future guidelines: areas for development. Osteoarthritis Cartilage 1999; 7: 4246.
  • 4
    Vignon E, Conrozier T, Piperno M, Richard S, Carrillon Y, Fantino O. Radiographic assessment of hip and knee osteoarthritis. Recommendations: recommended guidelines. Osteoarthritis Cartilage 1999; 7: 4346.
  • 5
    FDA/CDER resource page. Food and Drug Administration Web site. Guidance for industry: clinical development programs for drugs, devices, and biological products intended for the treatment of osteoarthritis. Available at: Accessed November 28, 2002.
  • 6
    The European Agency for the Evaluation of Medicinal Products Human Medicines Committee for proprietary medicinal products (CTMP) points to consider on the clinical investigation of medicinal products used in the treatment of osteoarthritis. Available at: Accessed November 28, 2002.
  • 7
    Lequesne M. Quantitative measurement of joint space during progression of osteoarthritis: chondrometry. In: KuettnerKE, GoldbergV, editors. Osteoarthritis disorders. Rosemont, IL: American Academy of Orthopaedic Surgery; 1995. p. 424-44.
  • 8
    Dacre JE, Huskisson EC. The automatic assessment of knee radiographs in osteoarthritis using digital image analysis. Br J Rheumatol 1989; 28: 50610.
  • 9
    Buckland-Wright JC, Macfarlane DG, Williams SA, Ward RJ. Accuracy and precision of joint space width measurements in standard and macroradiographs of osteoarthritic knees. Ann Rheum Dis 1995; 54: 87280.
  • 10
    Conrozier T, Tron AM, Mathieu P, Vignon E. Quantitative assessment of radiographic normal and osteoarthritic hip joint space. Osteoarthritis Cartilage 1995; Suppl A: 817.
  • 11
    Conrozier T, Jousseaume CA, Mathieu P, Tron AM, Caton J, Bejui J, et al. Quantitative measurement of joint space narrowing progression in hip osteoarthritis: a longitudinal retrospective study of patients treated by total hip arthroplasty. Br J Rheumatol 1998; 17: 9618.
  • 12
    Conrozier T, Lequesne M, Favret H, Taccoen A, Maziéres B, Dougados M, et al. Measurement of the radiological hip joint space width: an evaluation of various methods of measurement. Osteoarthritis Cartilage 2001; 9: 2816.
  • 13
    Dougados M, Nguyen M, Berdah L, Maziéres B, Vignon E, Lequesne M. Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year placebo-controlled trial. Arthritis Rheum 2001; 44: 253945.
  • 14
    Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001; 357: 2516.
  • 15
    Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. A long-term, randomized, placebo-controlled, confirmatory trial on the effects of glucosamine sulfate on knee osteoarthritis progression. Osteoarthritis Cartilage 2000; 8 (Suppl): S67.
  • 16
    Mazzuca SA, Brandt KD, Katz BP. Is conventional radiography suitable for evaluation of a disease-modifying drug in patients with knee osteoarthritis? Osteoarthritis Cartilage 1997; 5: 21726.
  • 17
    Ravaud P, Auleley G, Chastang C, Rousselin B, Paolozzi L, Amor B, et al. Knee joint space width measurement: an experimental study in the influence of radiographic procedure and joint positioning. Br J Rheumatol 1996; 35: 7616.
  • 18
    Piperno M, Hellio MP, Le Graverand MP, Conrozier T, Bochu M, Mathieu P, et al. Quantitative evaluation of joint space width in femorotibial osteoarthritis: comparison of three radiographic views. Osteoarthritis Cartilage 1998; 6: 2529.
  • 19
    Mazzuca SA, Brandt KD, Dieppe PA, Doherty M, Katz BP, Lane KA. Effect of alignment of the medial tibial plateau and x-ray beam on apparent progression of osteoarthritis in the standing anteroposterior knee radiograph. Arthritis Rheum 2001; 44: 178694.
  • 20
    Ravaud P, Chastang C, Auleley GR, Giraudeau B, Royant V, Amor B, et al. Assessment of joint space width in patients with osteoarthritis of the knee: a comparison of 4 measuring instruments. J Rheumatol 1996; 23: 174955.
  • 21
    Altman R, Asch E, Bloch D, Bole G, Borenstien D, Brandt KD, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986; 29: 103949.
  • 22
    Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 8: 30710
  • 23
    Brandt KD, Mazzuca SA, Conrozier T, Dacre JE, Peterfy CG, Provvedini D, et al. Which is the best radiographic protocol for a clinical trial of a structure modifying drug in patients with knee osteoarthritis? J Rheumatol 2002; 29: 130820.
  • 24
    Peterfy CG, Li J, Duryea J, Lynch JA, Miaux Y, Genant HK. Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint space width measurement [abstract]. Arthritis Rheum 1998; 41 Suppl 9: S361.