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Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active-surveillance report

  1. Juan J. Gómez-Reino1,*,
  2. Loreto Carmona2,
  3. Vicente Rodríguez Valverde3,
  4. Emilio Martín Mola4,
  5. Maria Dolores Montero5

Article first published online: 1 AUG 2003

DOI: 10.1002/art.11137

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 48, Issue 8, pages 2122–2127, August 2003

Additional Information

How to Cite

Gómez-Reino, J. J., Carmona, L., Valverde, V. R., Mola, E. M. and Montero, M. D. (2003), Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active-surveillance report. Arthritis & Rheumatism, 48: 2122–2127. doi: 10.1002/art.11137

Author Information

  1. 1

    Hospital Clinico Universitario and Universidad de Santiago de Compostela, Santiago, Spain

  2. 2

    Hospital Clinico Universitario “San Carlos,” Madrid, Spain

  3. 3

    Hospital Universitario “Marques de Valdecilla” and Universidad de Cantabria, Santander, Spain

  4. 4

    Hospital Universitario “La Paz,” Madrid, Spain

  5. 5

    Agencia Española del Medicamento, Ministerio de Sanidad y Consumo, Madrid, Spain

*BIOBADASER (Sociedad Española de Reumatología), Calle Recoletos 9, 1A, Madrid 28001, Spain

Publication History

  1. Issue published online: 1 AUG 2003
  2. Article first published online: 1 AUG 2003
  3. Manuscript Accepted: 22 APR 2003
  4. Manuscript Received: 17 JAN 2003

Funded by

  • Agencia Española del Medicamento (Ministerio de Sanidad y Consumo)
  • Spanish Society of Rheumatology

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REFERENCES

  • 1
    Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, et al, the Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000; 343: 1594–602.
  • 2
    Maini R, St. Clair EW, Breedveld F, Furst D, Kalden J, Weisman M, et al, the ATTRACT Study Group. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase III trial. Lancet 1999; 354: 1932–9.
  • 3
    Taylor PC. Anti-tumor necrosis factor therapies. Curr Opin Rheumatol 2001; 13: 164–9.
  • 4
    Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, et al. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. N Engl J Med 2001; 345: 1098–104.
  • 5
    SESPAS (Sociedad Española de Salud Publica). 2002 SEPAS report: investing in health. In: CabasesJM, VillalbiJR, AibarC, editors. Priorities for public health in Spain. Granada (Spain): Escuela Andaluza de Salud Publica; 2002. p. 21–42.
  • 6
    Carmona L, González-Álvaro I, Sanmartí R, Alejandro B, Tena X, Belmonte MA, et al, the EMECAR Study Group. Rheumatoid arthritis is associated to a four-fold increase in tuberculosis infection incidence in the pre-biologics era [abstract]. Arthritis Rheum 2001; 44 Suppl 9: S173.
  • 7
    Phillips K, Husni ME, Karlson EW, Coblyn JS. Experience with etanercept in an academic medical center: are infection rates increased? Arthritis Care Res 2002; 47: 17–21.
    Direct Link:
  • 8
    Wolfe F, Flowers N, Anderson J, Urbansky K. Tuberculosis rates are not increased in rheumatoid arthritis (RA) [abstract]. Arthritis Rheum 2001; 44 Suppl 9: S105.
  • 9
    Dursun AB, Kalac B, Yilmaz F. Pulmonary tuberculosis in patients with rheumatoid arthritis (four case reports). Rheumatol Int 2002: 21: 153–7.
  • 10
    Bynymin K, Cooper RG. Late reactivation of spinal tuberculosis by low-dose methotrexate therapy in a patient with rheumatoid arthritis. Rheumatology (Oxford) 2001; 40: 341–2.
  • 11
    Hernandez-Cruz B, Sifuentes-Osornio J, Ponce de Leon Garduno A, Diaz-Jouanen E. Mycobacterium tuberculosis infection in patients with systemic rheumatic diseases: a case-series. Clin Exp Rheumatol 1999; 17: 289–96.
  • 12
    Haas C, Youinou P. Tuberculosis and rheumatoid arthritis (a propos of 4 cases). Ann Med Interne (Paris) 1996; 147: 375–7.
  • 13
    Calpe J, Chiner E, Marin J, Martinez C, Lopez M, Sanchez E. Tuberculosis notification from 1987 to 1999 for the public health area of the community of Valencia (Spain). Arch Bronconeumol 2001; 37: 417–23.
  • 14
    Small P, Fujiwara PI. Management of tuberculosis in the United States. N Engl J Med 2001; 345: 189–200.
  • 15
    Wallis WJ, Burge DJ, Sabath D, Gardiner M. Tuberculosis reports with etanercept (Enbrel) therapy [abstract]. Arthritis Rheum 2001; 44 Suppl 9: S78.
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