SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Poole AR, Howell DS. Etiopathies of osteoarthritis. In: MoskowitzRW, HowellDS, AltmanRD, BuckwalterJA, GoldbergVM, editors. Osteoarthritis: diagnosis and medical/surgical management. 3rd ed. Philadelphia: Saunders; 2001. p. 2947.
  • 2
    Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT. The STR/ort mouse and its use as a model of osteoarthritis: a review. Osteoarthritis Cartilage 2001; 9: 8591.
  • 3
    Visco DM, Orevillo CJ, Kammerman J, Kincaid SA, Widmer WR, Christen AJ, et al. Is the murine partial medial menisectomy model a useful animal model? [abstract]. Trans Orthop Res Soc 1998; 23: 876.
  • 4
    Saklatvala J. Interleukin-1: purification and biochemical aspects of its action on cartilage. J Rheumatol 1987; 14 Special: 524.
  • 5
    Dodge GR, Poole AR. Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1. J Clin Invest 1989; 83: 64761.
  • 6
    Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, et al. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum 2000; 43: 66472.
  • 7
    Tyler JA, Benton HP. Synthesis of type II collagen is decreased in cartilage cultured with IL-1 while the rate of intracellular degradation remains unchanged. Coll Rel Res 1988; 8: 393405.
  • 8
    Arner EC, Pratta MA. Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture. Arthritis Rheum 1989; 32: 28897.
  • 9
    Lefebvre V, Peeters-Joris C, Vaes G. Modulation by IL-1 and TNFα of production of collagenases, tissue inhibitors of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes. Biochim Biophys Acta 1990; 1052: 36678.
  • 10
    Arner EC, Tortorella MD. Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1. Arthritis Rheum 1995; 38: 130414.
  • 11
    Chambers MG, Bayliss MT, Mason RM. Chondrocyte cytokine growth factor expression in murine osteoarthritis. Osteoarthritis Cartilage 1997; 5: 3018.
  • 12
    Pelletier JP, Martel-Pelletier J. Evidence for the involvement of interleukin 1 in human osteoarthritic cartilage degradation: protective effect of NSAID. J Rheumatol Suppl 1989; 18: 1927.
  • 13
    Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, et al. IL-1β-converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31 Kda IL-1α. J Immunol 1991; 147: 29649.
  • 14
    Saha N, Moldovan F, Tardif G, Pelletier J-P, Cloutier J-M, Martel-Pelletier J. Interleukin-1β–converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1β and interleukin-18. Arthritis Rheum 1999; 42: 157787.
  • 15
    Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993; 75: 65360.
  • 16
    Freemont AJ, Hampson V, Tilman R, Goupille P, Taiwo Y, Hoyland JA. Gene expression of matrix metalloproteinases 1, 3 and 9 by chondrocytes in osteoarthritic human knee cartilage is zone and grade specific. Ann Rheum Dis 1997; 56: 5429.
  • 17
    Brinckerhoff CE, Suzuki K, Mitchell TI. Rabbit procollagenase synthesized and secreted by a high yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation. J Biol Chem 1990; 265: 222629.
  • 18
    Ogata Y, Enghild JJ, Nagase H. MMP-3 (stromelysin) activates the precursor for the human MMP-9. J Biol Chem 1992; 267: 35814.
  • 19
    Wu JJ, Lark MW, Chun LE, Eyre DR. Sites of stromelysin cleavage in collagen types II, IX, X and XI of cartilage. J Biol Chem 1991; 266: 56258.
  • 20
    Olszewski J, Moore VL, McDonnell J, Williams H, Saphos CA, Green BG, et al. Proteoglycan degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints: quantitation of proteoglycan and stromelysin-induced HABR fragments of aggrecan in synovial fluid and cartilage. Connect Tissue Res 1996; 33: 2919.
  • 21
    Eyre DR, Wu JJ, Woods P. The cartilage-specific collagens: structural studies. In: KuettnerKE, SchleyerbachR, PeyronJG, HascallVC, editors. Articular cartilage and osteoarthritis. New York: Raven Press; 1992. p. 11931.
  • 22
    Van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, et al. Cleavage of aggrecan at the Asn341–Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity. Arthritis Rheum 1999; 42: 207484.
  • 23
    Farrell AJ, Blake DR, Palmer RM, Moncada S. Increased concentration of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992; 51: 121922.
  • 24
    Van de Loo FAJ, Arntz OJ, van Enckevort FHJ, van Lent PLEM, van den Berg WB. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti–interleukin-1–treated wild-type mice with unabated joint inflammation. Arthritis Rheum 1998; 41: 63446.
  • 25
    Stefanovic-Racic M, Mollers MO, Miller LA, Evans CH. Nitric oxide and proteoglycan turnover in rabbit articular cartilage. J Orthop Res 1997; 15: 4429.
  • 26
    Cao M, Westerhausen-Larson A, Niyibizi C, Kavalhovich K, Georgescu HI, Rizzo CF, et al. Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J 1997; 324: 30510.
  • 27
    Murrell GAC, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 1995; 206: 1521.
  • 28
    Stefanovic-Racic M, Morales TI, Taskiran D, McIntyre LA, Evans CH. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol 1996; 156: 121320.
  • 29
    Pelletier JP, Mineau F, Ranger P, Tardif G, Martel-Pelletier J. The increased synthesis of inducible nitric oxide inhibits IL-1Ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. Osteoarthritis Cartilage 1996; 4: 7784.
  • 30
    Blanco FJ, Guitian R, Vázquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 1998; 41: 2849.
  • 31
    Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic cartilage. J Clin Invest 1997; 99: 153445.
  • 32
    Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI. Aggrecan degradation in human cartilage: evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic and rheumatoid joints. J Clin Invest 1997; 100: 93106.
  • 33
    Sandy JD, Neame PJ, Boynton RE, Flannery CR. Catabolism of aggrecan in cartilage explants. J Biol Chem 1991; 266: 86835.
  • 34
    Stoop R, van der Kraan PM, Buma P, Hollander AP, Billinghurst RC, Poole AR, et al. Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice. Arthritis Rheum 1999; 42: 23819.
  • 35
    Price JS, Chambers MG, Poole AR, Fradin A, Mason RM. Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis. Osteoarthritis Cartilage 2002; 10: 1729.
  • 36
    Chambers MG, Cox L, Chong L, Suri N, Cover P, Bayliss MT, et al. Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice. Arthritis Rheum 2001; 44: 145565.
  • 37
    Zheng H, Fletcher D, Kozak W, Jiang M, Hofmann KJ, Conn CA, et al. Resistance to fever induction and impaired acute-phase response in interleukin-1β–deficient mice. Immunity 1995; 3: 919.
  • 38
    Mudgett JS, Hutchinson NI, Chartrain NA, Forsyth AJ, McDonnell J, Singer II, et al. Susceptibility of stromelysin-1–deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum 1998; 41: 11021.
  • 39
    Tocci MJ. Structure and function of interleukin-1 beta converting enzyme. Vitam Horm 1997; 53: 2763.
  • 40
    MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995; 81: 64150.
  • 41
    Scott JE, Dorling J. Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions. Histochemie 1965; 5: 22133.
  • 42
    Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebe T, et al. ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem 2002: 277; 1605966.
  • 43
    Hashimoto S, Ochs RL, Komiya S, Lotz M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998; 41: 16328.
  • 44
    Heraud F, Heraud A, Harmand MF. Apoptosis in normal and osteoarthritic human articular cartilage. Ann Rheum Dis 2000; 59: 95965.
  • 45
    Horai R, Asano M, Sudo K, Kanuta H, Suzuki M, Nishihara M, et al. Production of mice deficient in genes for interleukin-1 (IL)-1α, IL-1β, IL-1α/β and the IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 1998; 187: 146375.
  • 46
    Saklatvala J, Guesdon F. Interleukin-1 and tumor necrosis factor signal transduction mechanisms: potential targets for pharmacological control of inflammation. J Rheumatol Suppl 1992; 32: 6570.
  • 47
    Van den Berg WB. Arguments for interleukin-1 as a target in chronic arthritis. Ann Rheum Dis 2000; 59 Suppl I: i814.
  • 48
    JoostenLAB, Helsen MMA, van de Loo FAJ, van den Berg WB. Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti–IL-1α/β, and IL-1Ra. Arthritis Rheum 1996; 39: 797809.
  • 49
    Fantuzzi G, Sacco S, Ghezzi P, Dinarello CA. Physiological and cytokine responses in IL-1beta-deficient mice after zymosan-induced inflammation. Am J Physiol 1997; 273: R4006.
  • 50
    Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. Osteoarthritis Cartilage 1998; 6: 21428.
  • 51
    Nagase H. Stromelysin-2. In: BarrettAJ, RawlingsND, WoessnerFF, editors. Handbook of proteolytic enzymes. London: Academic Press; 1998. p. 117880.
  • 52
    Bord S, Horner A, Beeton CA, Hembry RM, Compston JE. Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone. Bone 1999; 24: 22935.
  • 53
    Hazuda DJ, Strickler J, Kueppers F, Simon PL, Yong PR. Processing of precursor interleukin 1β and inflammatory disease. J Biol Chem 1990; 265: 631822.
  • 54
    Miwa K, Asano M, Horai R, Iwakura Y, Nagata S, Suda T. Caspase-1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med 1998; 4: 128792.
  • 55
    Pelletier JP, Lascau-Coman V, Jovanovic D, Fernandes JC, Manning P, Connor JR, et al. Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol 1999; 26: 200214.
  • 56
    Van der Kraan PM, Vitters EL, van Beuningen HM, van de Loo FA, van den Berg WB. Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. Osteoarthritis Cartilage 2000; 8: 826.
  • 57
    Cohen N, Robinson D, Ben-Ezzer J, Hemo Y, Hasharoni A, Wolmann Y, et al. Reduced NO accumulation in arthrotic cartilage by exposure to methylene blue. Acta Orthop Scand 2000; 71: 6206.