Synovial fluid lipids in normal individuals and patients with rheumatoid arthritis


  • Giles G. Bole Jr. M.D.,

    1. Assistant Professor of Medicine, The University of Michigan Medical School, Ann Arbor, Mich. Postdoctoral Research Fellow, Arthritis and Rheumatism Foundation
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  • Dorothy F. Peltier

    Technical Assistance
    1. Research Assistant, Rackham Arthritis Research Unit, The University of Michigan Medical School, Ann Arbor, Mich.
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Normal human synovial fluid contains trace amounts of phospholipids and cholesterol. Phospholipid composition is similar to that in serum. Rheumatoid synovial fluid contains increased amounts of phospholipid, cholesterol, and neutral lipids. In most cases the concentration is 40 to 60 per cent of that found in simultaneously collected serum specimens. A direct relationship appears to exist between total synovial fluid protein and lipid concentration. No relationship could be established between lipid content in rheumatoid synovial fluid, and total cell content, hyaluronic acid, severity or duration of synovitis in the involved joint.


Normal liquido synovial in humanos contine quantitates tracia de phospholipidos e de cholesterol. Iste phospholipidos es simile in composition a illos del sero. Le liquido synovial ab patientes rheumatoide contine augmentate quantitates de phospholipido, de cholesterol, e de lipidos neutre. In le majoritate del casos, le concentration es 40 a 60 pro cento de illo trovate in simultaneemente colligite specimens de sero. Un relation directe pare exister inter le proteina total e le concentration lipidic in le liquido synovial. Nulle relation poteva esser establite inter le contento de lipidos in liquido synovial ab patientes rheumatoide e le parametros del total contento cellular, de acido hyaluronic, e del severitate o del duration de synovitis in le afficite articulation.