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Abstract

In 10 patients with Wegener's granulomatosis, low doses of cyclophosphamide produced: severe lymphocytopenia of long duration even after therapy ceased; a greater percentage decrease in nonrosette forming lymphocytes than in rosette forming T-lymphocytes; normal in vitro lymphocyte responses to mitogens (PHA, ConA, and PWM) with suppressed responses to one of two antigens tested (SK-SD). This regimen did not cause severe granulocytopenia and was successful in inducing and maintaining long-term clinical remissions.