Nailfold capillary abnormalities and clinical outcome in childhood dermatomyositis

Authors

  • George Spencer-Green MD,

    Assistant Professor of Medicine, Corresponding author
    1. Division of Immunology, Departments of Medicine and Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH.
    • Division of Immunology, Department of Medicine, University of Cincinnati Medical Center, 231 Bethesda Avenue, Cincinnati, OH 45267
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  • William E. Crowe MD,

    Assistant Professor of Medicine and Pediatrics
    1. Division of Immunology, Departments of Medicine and Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH.
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  • Joseph E. Levinson MD

    Professor of Medicine and Pediatrics
    1. Division of Immunology, Departments of Medicine and Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH.
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Abstract

The nailfold capillary pattern was observed in a population of patients with childhood dermatomyositis. Distinctive nailfold capillary loop abnormalities were found in 11 of 19 childhood dermatomyositis patients and in none of 2 control populations (P < 0.001). By a retrospective analysis of the childhood dermatomyositis patients, we found that the presence of nailfold capillary abnormalities correlates with more severe forms of the disease (ulcerative and chronic types), as opposed to limited type of disease. These changes occurred independently of disease activity or of cutaneous abnormalities.

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