The significance of thrombocytopenia in systemic lupus erythematosus

Authors

  • Marian H. Miller MB, BS, FRACP,

    1. University of Toronto Rheumatic Disease Unit, The Wellesley Hospital and Women's College Hospital, Toronto, Ontario, Canada.
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  • Dr Murray B. Urowitz MD, RRCP(C),

    Profefssor of Medicine, Corresponding author
    1. University of Toronto Rheumatic Disease Unit, The Wellesley Hospital and Women's College Hospital, Toronto, Ontario, Canada.
    • The Wellesley Hospital, Rheumatic Disease Unit, 160 Wellesley St. E., Toronto, Ontario, M4Y 1J3, Canada
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  • Dafna D. Gladman MD, RRCP(C)

    Assstant Profefssor of Medicine
    1. University of Toronto Rheumatic Disease Unit, The Wellesley Hospital and Women's College Hospital, Toronto, Ontario, Canada.
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Abstract

The significance of thrombocytopenia in systemic lupus erythematosus (SLE) is unclear. Some researchers have found it associated with severe disease, others with mild disease. Thrombocytopenia (platelets < 100,000) occurred in 21 patients seen at an SLE clinic over 18 months. Prospective assessment of 19 (non-SLE causes excluded) revealed 2 distinct subgroups. Seven were thrombocytopenic only during severe multisystem flares. Twelve had chronic thrombocytopenia with intermittent mild flares in other systems. Serious bleeding was rare in both subgroups. It was concluded that thrombocytopenia clearly is not a prognostic indicator.

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