Ro (SS-A) antibody and antigen in a patient with congenital complete heart block

Authors

  • Dr. John B. Harley MD, PhD,

    Assistant Professor Of Medicine, Corresponding author
    1. University of Oklahoma Health Sciences Center, and Affiliated Assistant Professor, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City
    • Department of Medicine, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190
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  • Jeffrey L. Kaine MD,

    Assistant Professor of Medicine
    1. Washington University School of Medicine, St. Louis, Missouri
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  • Owen F. Fox PhD,

    Staff Scientist
    1. Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City
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  • Morris Reichlin MD,

    Head and Professor of Medicine
    1. Arthritis and Immunology Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City
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  • Barry Gruber MD

    Fellow in Rheumatology
    1. State University of New York at Stony Brook, Stony Brook, New York
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Abstract

Congenital complete heart block is closely associated with the presence of anti-Ro (SS-A) autoantibodies. Quantitative solid-phase assays for Ro (SS-A) autoantigen and autoantibody have established the presence of Ro (SS-A) in cardiac tissues and have been used to evaluate an informative pedigree. The propositus we describe here had complete congenital heart block and showed anti–Ro (SS-A) binding of 13-fold less than his normal HLA-identical twin sister. Both had identical titers of antinuclear antibody. These data support the hypothesis that anti–Ro (SS-A) may be directly involved in the pathogenesis of congenital complete heart block.

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