Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus

Authors

  • Rosalind Ramsey-Goldman MD,

    Fellow, Corresponding author
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
    • Department of Medicine, 985 Scaife Hall, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
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  • David Hom MS,

    Graduate Student, Department of Epidemiology
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • Jau-Shyong Deng MD,

    Assistant Professor of Dermatology
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • Gayle Casterline Ziegler RN, BSN,

    Research Assistant
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • Leslie E. Kahl MD,

    Assistant Professor of Medicine
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • Virginia D. Steen MD,

    Assistant Professor of Medicine
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • Ronald E. Laporte PhD,

    Assistant Professor of Epidemiology
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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  • THOMAS A. Medsger Jr. MD

    Professor of Medicine
    1. Departments of Medicine (Division of Rheumatology and Clinical Immunology) and Dermatology, University of Pittsburgh School of Medicine, and the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
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Abstract

In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti-SS-A antibody and the 108 without anti-SS-A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti-SS-A and was associated with high-titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti-SS-A antibody was present.

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