PREVALENCE OF COXSACKIE B VIRUS ANTIBODIES IN PATIENTS WITH JUVENILE DERMATOMYOSITIS

Authors

  • MARY L. Christensen PhD,

    Director, Corresponding author
    1. Departments of Pathology and Pediatrics, Childen's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois
    2. Division of Clinical Genetics, Department of Obstetrics and Gynecology and the Department of Pediatrics, University of Texas Health Science Center at Dallas
    • Virology Laboratory, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614
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  • Lauren M. Pachman MD,

    Head
    1. Departments of Pathology and Pediatrics, Childen's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois
    2. Division of Clinical Genetics, Department of Obstetrics and Gynecology and the Department of Pediatrics, University of Texas Health Science Center at Dallas
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  • Richard Schneiderman BS,

    1. Departments of Pathology and Pediatrics, Childen's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois
    2. Division of Clinical Genetics, Department of Obstetrics and Gynecology and the Department of Pediatrics, University of Texas Health Science Center at Dallas
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  • Devendrakumar C. Patel BS,

    1. Departments of Pathology and Pediatrics, Childen's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois
    2. Division of Clinical Genetics, Department of Obstetrics and Gynecology and the Department of Pediatrics, University of Texas Health Science Center at Dallas
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  • Jan M. Friedman Md, Phd

    Associate Professor
    1. Departments of Pathology and Pediatrics, Childen's Memorial Hospital and Northwestern University Medical School, Chicago, Illinois
    2. Division of Clinical Genetics, Department of Obstetrics and Gynecology and the Department of Pediatrics, University of Texas Health Science Center at Dallas
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  • Presented in part at the 47th Annual Meeting of the American Rheumatism Association, San Antonio, TX, June 1983

Abstract

A number of viruses have been implicated as being the cause of various forms of myositis, including acute transient myositis, chronic polymyositis, and dermatomyositis. However, the cause of juvenile dermato-myositis (JDM) has remained elusive. Our study of serum samples taken within 4 months of the onset of disease in 12 children with JDM showed that 83% had detectable titers of complement-fixing (CF) antibody to 1 or more coxsackie B viral antigens. Detectable titers were found in only 25% of age-, sex-, and date-matched control sera taken from 24 patients with juvenile rheumatoid arthritis (JRA), and in 25% of serum samples taken from 2,192 “normal” children who had been hospitalized because of viral syndromes. Titers of CF antibody to coxsackie B1, B2, and B4 were positive in 58%, 50%, and 58%, respectively, of the JDM patients. In matched JRA controls, the respective values were 8%, 13%, and 8%. There were no significant antiviral titers and no significant differences in the results of tests for 13 other viral CF antigens, hepatitis B surface antigen, and Mycoplasma pneumoniae CF antigen in the JDM patient sera compared with the JRA patient sera. When titers of neutralizing antibody were determined, 58%, 58%, and 67% of the JDM patients were positive for coxsackie B2, B4, and B5, respectively, whereas 16%, 26%, and 21%, respectively, of the JRA controls were positive for the 3 antigens. These data suggest that the host response to coxsackie B virus might be related to the pathophysiology of JDM.

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