Article

Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography

  1. Mark W. Layton MD Postdoctoral Fellow1,†,
  2. Steven A. Goldstein PhD Section of Orthopaedic Surgery4,*,
  3. Robert W. Goulet MS Graduate Student, Bioengineering Program4,
  4. Lee A. Feldkamp PhD1,4,
  5. David J. Kubinski MS2,4,
  6. Giles G. Bole MD3,4

Article first published online: 29 NOV 2005

DOI: 10.1002/art.1780311109

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 31, Issue 11, pages 1400–1405, November 1988

Additional Information

How to Cite

Layton, M. W., Goldstein, S. A., Goulet, R. W., Feldkamp, L. A., Kubinski, D. J. and Bole, G. G. (1988), Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis & Rheumatism, 31: 1400–1405. doi: 10.1002/art.1780311109

Author Information

  1. 1

    Research Staff, Physics Department, Ford Motor Company, Dearborn, Michigan

  2. 2

    Research Staff, Physics Department, Ford Motor Company, Dearborn, Michigan

  3. 3

    Division of Rheumatology, University of Michigan

  4. 4

    Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.

  1. †

    Olympia Arthritis and Rheumatic Disease Clinic, Olympia, Washington

*Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, G-0161 400 North Ingalls, Ann Arbor, MI 48109--0486

Publication History

  1. Issue published online: 29 NOV 2005
  2. Article first published online: 29 NOV 2005
  3. Manuscript Accepted: 9 JUN 1988
  4. Manuscript Received: 2 NOV 1987

Funded by

  • NIH. Grant Numbers: T32-AM-7080, AR-31793, AR-34399
  • Michigan Chapter of the Arthritis Foundation.

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Abstract

Subchondral bone changes have been proposed as an early event in the pathogenesis of osteoarthritis. In this study, microscopic computed axial tomography was used to evaluate the subchondral bone structure in femoral heads from a guinea pig model of osteoarthritis. Examination of trabecular bone within the femoral head showed a highly significant increase in bone fraction in the experimental animals. This was due to the development of trabeculae that were thicker and closer together. We conclude that trabecular remodeling may be an early event in this model of osteoarthritis.

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