Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography

Authors

  • Mark W. Layton MD,

    Postdoctoral Fellow
    1. Research Staff, Physics Department, Ford Motor Company, Dearborn, Michigan
    Current affiliation:
    1. Olympia Arthritis and Rheumatic Disease Clinic, Olympia, Washington
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  • Steven A. Goldstein PhD,

    Section of Orthopaedic Surgery, Corresponding author
    1. Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.
    • Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, G-0161 400 North Ingalls, Ann Arbor, MI 48109--0486
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  • Robert W. Goulet MS,

    Graduate Student, Bioengineering Program
    1. Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.
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  • Lee A. Feldkamp PhD,

    1. Research Staff, Physics Department, Ford Motor Company, Dearborn, Michigan
    2. Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.
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  • David J. Kubinski MS,

    1. Research Staff, Physics Department, Ford Motor Company, Dearborn, Michigan
    2. Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.
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  • Giles G. Bole MD

    1. Division of Rheumatology, University of Michigan
    2. Rackham Arthritis Research Unit, Department of Internal Medicine, and the Biomechanics, Trauma, and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor.
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Abstract

Subchondral bone changes have been proposed as an early event in the pathogenesis of osteoarthritis. In this study, microscopic computed axial tomography was used to evaluate the subchondral bone structure in femoral heads from a guinea pig model of osteoarthritis. Examination of trabecular bone within the femoral head showed a highly significant increase in bone fraction in the experimental animals. This was due to the development of trabeculae that were thicker and closer together. We conclude that trabecular remodeling may be an early event in this model of osteoarthritis.

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