• 1
    . McMichael AJ, Sasazuki T, McDevitt HD, Payne RO: Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. Arthritis Rheum 20: 10371042, 1977
  • 2
    . Stastny P: Association of the B-cell alloantigen DR4 with rheumatoid arthritis. N Engl J Med 298: 669671, 1978
  • 3
    . Jaraquemada D, Ollier W, Awad J, Young A, Silman A, Roitt IM, Corbett M, Hay F, Cosh JA, Maini RN, Venables PJ, Ansell B, Hollborow J, Reeback J, Currey HLF, Festenstein H: HLA and rheumatoid arthritis: a combined analysis of 440 British patients. Ann Rheum Dis 45: 627636, 1986
  • 4
    . Rossen RD, Brewer EJ, Sharp RM, Ott J, Templeton JW: Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis. J Clin Invest 65: 629642, 1980
  • 5
    . Seligmann M: Human lymphocyte subsets in health and disease, Progress in Immunology. Vol. 5. Edited by YYamamura, TTada. New York, Academic Press, 1984
  • 6
    . Lydyard PM, Youinou P, Cooke A: CD5-positive B cells in rheumatoid arthritis and chronic lymphocytic leukemia. Immunol Today 8: 3739, 1987
  • 7
    . Youinou P, Mackenzie L, Bröker BM, Isenberg DA, Drogou-Lelong A, Gentric A, Lydyard PM: The importance of CD5-positive B cells in nonorgan-specific autoimmune diseases. Scand J Rheumatol [Suppl] 263269, 1988
  • 8
    . Casali P, Burastero SE, Nakamura M, Inghirami G, Notkins AL: Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1 positive B-cell subset. Science 236: 7781, 1987
  • 9
    . Hardy RR, Hayakawa K, Shimizu M, Yamasaki K, Kishimoto T: Rheumatoid factor secretion from human Leu-1 positive B cells. Science 236: 8183, 1987
  • 10
    . Bröker BM, Klajman A, Youinou P, Jouquan J, Worman CP, Murphy J, Mackenzie L, Quartey-Papafio R, Blaschek M, Collins P, Lal S, Lydyard PM: Chronic lymphocytic leukemic cells secrete multispecific autoantibodies. J Autoimmun 1: 469481, 1988
  • 11
    . Nakamura M, Burastero SE, Notkins AL, Casali P: Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1) positive B cells are polyreactive. J Immuncl 140: 41804196, 1988
  • 12
    . Caligaris-Cappio F, Gobbi M, Bofill M, Janossy G: Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia. J Exp Med 155: 623628, 1982
  • 13
    . Youinou P, Lydyard PM: Receptor for mouse erythrocytes on human immature B cells: still a valuable tool in immunohematology. Diagn Clin Immunol 5: 112114, 1987
  • 14
    . Youinou P, Mackenzie L, Jouquan J, Le Goff P, Lydyard PM: CD5 positive B cells in patients with rheumatoid arthritis: phorbol ester mediated enhancement of detection. Ann Rheum Dis 46: 1722, 1987
  • 15
    . Youinou P, Mackenzie L, Le Masson G, Papadopoulos NM, Jouquan J, Pennec YL, Angelidis P, Katsikis P, Moutsopoulos HM, Lydyard PM: CD5-expressing B lymphocytes in the blood and salivary glands of patients with primary Sjögren's syndrome. J Autoimmun 1: 185194, 1988
  • 16
    . Plater-Zyberk C, Maini RN, Lam K, Kennedy TD, Janossy G: A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia. Arthritis Rheum 28: 971976, 1985
  • 17
    . Dauphinée MJ, Kincaid W, Talal N: A B cell subset with T cell marker is elevated in rheumatoid arthritis (abstract). Arthritis Rheum 29 (suppl 4): S83, 1986
  • 18
    . Taniguchi O, Miyagima H, Hirano T, Noguchi M, Ueda A, Hashimoto H, Hirose S, Okumura K: The leu-1 B cell subpopulation in patients with rheumatoid arthritis. J Clin Immunol 7: 441448, 1987
  • 19
    . Dauphinée M, Tovar Z, Talal N: B cells expressing CD5 are increased in Sjögren's syndrome. Arthritis Rheum 31: 642647, 1988
  • 20
    . Kipps TJ, Vaughan JH: Genetic influence on the levels of circulating CD5+ B lymphocytes. J Immunol 139: 10601064, 1987
  • 21
    . Hayakawa K, Hardy RR, Parks DR, Herzenberg LA: The “Ly-1 B” cell subpopulation in normal, immunodefective and autoimmune mice. J Exp Med 157: 202218, 1983
  • 22
    . Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315324, 1988
  • 23
    . Shoenfeld Y, IIsu-Lin SC, Gabriels JE, Silberstein LE, Furie BC, Furie B, Stollar BD, Schwartz RS: Production of autoantibodies by human-human hybridomas. J Clin Invest 70: 205208, 1982
  • 24
    . Carson DA, Laurance S, Catalano MA, Vaughan JH, Abraham G: Radioimmunoassay of IgG and IgM rheumatoid factor reacting with human IgG. J Immunol 119: 295300, 1977
  • 25
    . Youinou P, Le Goff P, Casburn-Budd R, Ferec C, Pennec Y: Evidence for relationships between antiperinuclear and IgG rheumatoid factor. Rheumatol Int 4: 111114, 1984
  • 26
    . Muzellec Y, Le Goff P, Jouquan J, Fauquert P, Muller S, Youinou P: Antibodies to histones in rheumatoid arthritis. Diagn Clin Immunol 5: 326331, 1988
  • 27
    . Muller S, Plane S, Couppez M, Van Regenmortel MHV: Comparison of different methods for localizing antigenic regions in histone H2A. Mol Immunol 23: 593601, 1986
  • 28
    . Barany G, Merrifield RB: Solid-phase peptide synthesis, The Peptides. Vol. 2. Edited by EGross, JMeinenhofer. New York, Academic Press, 1980
  • 29
    . Muller S, Couppez M, Briand JP, Gordon J, Sautière P, Van Regenmortel MHV: Antigenic structure of histone H2B. Biochim Biophys Acta 827: 235246, 1985
  • 30
    . Papadopoulos NM, Elin RJ, Wilson DM: Incidence of gamma globulin banding in the healthy population by high resolution electrophoresis. Clin Chem 28: 707709, 1982
  • 31
    . Pascali E, Pezzoli A, Chiarandin A: Immunofixation: application to the identification of “difficult” monoclonal gammopathies. Clin Chem 28: 14041409, 1982
  • 32
    . Hardy RR, Hayakawa K: Development and physiology of Ly-1 B and its human homolog Leu-1 B. Immunol Rev 93: 5381, 1986
  • 33
    . Hayakawa K, Hardy RR, Honda M, Herzenberg LA, Steinberg AD, Herzenberg LA: Ly-1 B cells, functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci USA 81: 24942498, 1984
  • 34
    . Maini RN, Plater-Zyberk C, Andrew E: Autoimmunity in rheumatoid arthritis: an approach via a study of B lymphocytes. Rheum Dis Clin North Am 13: 319338, 1987
  • 35
    . Yamada H, Shimizu H, Taniguchi O, Okumura K: Leu-1 (CD5) B cell subpopulation in patients with various liver diseases: special reference to hepatitis B virus carrier and to changes caused by prednisolone therapy. Int Arch Allergy Appl Immunol 87: 409416, 1988
  • 36
    . Merètey K, Gögényi F, Gyody E, Petramyi GG: Study of autoantibodies, natural antibodies and IgE level in four families with rheumatoid arthritis. Z Rheumatol 46: 189195, 1987
  • 37
    . Agnello V, Arbetter A, Ibanez de Kasep G, Powell R, Tan EM, Joslin F: Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype. J Exp Med 151: 15141527, 1980
  • 38
    . Pasquali JL, Azerad G, Martin T, Muller S: The double reactivity of a human monoclonal rheumatoid factor to IgG and histones is related to distinct binding sites. Eur J Immunol 18: 11271130, 1988
  • 39
    . Rekvig OP, Muller S, Briand JP, Skogen B, Van Regenmortel MHV: Human antinuclear autoantibodies crossreacting with the plasma membrane and the N-terminal region of histone H2B. Immunol Invest 16: 535547, 1987
  • 40
    . Muller S, Bonnier D, Thiry M, Van Regenmortel MHV: Reactivity of autoantibodies in systemic lupus erythematosus with synthetic core histone peptides. Int Arch Allergy Appl Immunol 89: 288296, 1989
  • 41
    . Burastero SE, Casali P, Wilder RL, Notkins AL: Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J Exp Med 168: 19791992, 1988
  • 42
    . Braun J: Spontaneous in vitro occurrence and long-term culture of murine B lymphoblast cell lines. J Immunol 130: 21132116, 1983
  • 43
    . Hayakawa K, Hardy RR, Herzenberg LA: Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol 16: 450456, 1986
  • 44
    . Youinou P, Le Goff P, Renier JC, Hurez D, Miossec P, Morrow WJW: Relationship between rheumatoid arthritis and monoclonal gammopathy. J Rheumatol 10: 210215, 1983
  • 45
    . Sidebottom D, Grennan DM, Sanders PA, Read A: Immunoglobulin lambda light chain genes in rheumatoid arthritis. Ann Rheum Dis 46: 587589, 1987
  • 46
    . Sherr DH, Dorf ME: An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants. J Exp Med 159: 11891200, 1984
  • 47
    . Okumura K, Hayakawa K, Tada T: Cell-to-cell interaction controlled by immunoglobulin genes: role of Thy-1-, Lyt-1-, Lyt-1+, Ig+ (B′) cells in allotype-restricted antibody production. J Exp Med 156: 443453, 1982
  • 48
    . Youinou P, Williams W, Le Goff P, Tuaillon N, Jouquan J, Muller S, Isenberg DA: Serological abnormalities, including common idiotype PR4, in families with rheumatoid arthritis. Ann Rheum Dis 48: 898904, 1989