C3 activation products correlate with antibodies to lipid a in pauciarticular juvenile arthritis

Authors

  • Lynne C. Olds BS,

    1. Department of Biology, San Jose State University
    2. Children's Hospital at Stanford, Stanford University School of Medicine, Palo Alto, California.
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  • John J. Miller III MD, PhD

    Corresponding author
    1. Stanford University School of Medicine
    2. Children's Hospital at Stanford, Stanford University School of Medicine, Palo Alto, California.
    • Children's Hospital at Stanford, 520 Sand Hill Road, Palo Alto. CA 94304
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Abstract

IgM antibodies to monophosphoryl-lipid A were found to be elevated in sera from children with all forms of juvenile arthritis (JA) and systemic lupus erythematosus. Of more interest, in patients with pauciarticular JA, IgG antibody titers to monophosphoryl-lipid A were found to be correlated with the C3a concentration and the C3d:C3 ratio. Although the full specificity of these antibodies is unknown, they are the first that have been found to be correlated with complement activation products in any form of JA.

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