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Article
Antihistone antibodies in antinuclear antibody—positive juvenile Arthritis
Article first published online: 9 DEC 2005
DOI: 10.1002/art.1780331212
Copyright © 1990 American College of Rheumatology
1529-0131/asset/cover.gif?v=1&s=104d5c2bb8ef72deba26790b855af7ab80697a0e "Arthritis & Rheumatism")
Additional Information
How to Cite
Monestier, M., Losman, J. A., Fasy, T. M., Debbas, M. E., Massa, M., Albani, S., Bohm, L. and Martini, A. (1990), Antihistone antibodies in antinuclear antibody—positive juvenile Arthritis. Arthritis & Rheumatism, 33: 1836–1841. doi: 10.1002/art.1780331212
Publication History
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Accepted: 11 JUN 1990
- Manuscript Received: 12 MAR 1990
Funded by
- NIH. Grant Number: AI-26665
- Lupus Foundation of America
- CNR
- Abstract
- References
- Cited By
Abstract
The binding of antinuclear antibody—positive juvenile arthritis (JA) sera to bovine thymus histones H1, H2A, H2B, H3, and H4 was studied by an enzyme-linked immunosorbent assay. Seventy-five percent of the JA patients tested positive for at least 1 antibody specificity. Antihistone antibodies were predominantly IgM, while IgG antibodies were less common and were restricted to histones H1 or H3. In the group of patients with JA of pauciarticular onset, antihistone antibodies were significantly more elevated in patients with past or present uveitis than in patients without a history of uveitis. Anti-H1 antibodies in JA patients were found to react mostly with determinants located in the carboxylterminal domain of the H1 molecule. Sera were also reactive with human histone H1° or chicken histone H5, which are H1 variants found only in nondividing cells.