Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia

Authors

  • Clodoveo Ferri MD,

    Corresponding author
    1. Rheumatology Unit and Clinical Immunology Unit, University of Pisa
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
    • Istituto di Patologia Medica I, Via Roma, 67, 56100 Pisa, Italy
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  • Francesco Greco MD,

    1. Ospedale S. Chiara
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Giovanni Longombardo BS,

    1. Rheumatology Unit and Clinical Immunology Unit, University of Pisa
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Piero Palla MD,

    1. Blood Center, Ospedale S. Chiara
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Adolfo Moretti MD,

    1. Blood Center, Ospedale S. Chiara
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Emanuele Marzo MD,

    1. Rheumatology Unit and Clinical Immunology Unit, University of Pisa
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Pier Vittorio Fosella MD,

    1. Blood Center, Ospedale S. Chiara
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Giampiero Pasero MD,

    1. Rheumatology Unit and Clinical Immunology Unit, University of Pisa
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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  • Stefano Bombardieri MD

    1. Rheumatology Unit and Clinical Immunology Unit, University of Pisa
    2. Rheumatology Unit and Clinical Immunology Unit, University of Pisa, and the Blood Center, Ospedale S. Chiara, Pisa, Italy
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Abstract

The prevalence of antibodies to hepatitis C virus (HCVAb) was investigated in 52 unselected patients with mixed cryoglobulinemia and in 84 patients with other systemic immunologic diseases. HCVAb were detected by an enzyme-linked immunosorbent assay, and their specificity was evaluated by a recombinant-based immunoblot assay. The presence of HBV-related markers was investigated in the same samples. HCVAb were found in 54% of mixed cryoglobulinemia patients, and the finding was confirmed by recombinant-based immunoblot assay in all cases. HCVAb and/or HBV markers were present in 70% of the patients. HCVAb seropositivity was significantly more frequent in mixed cryoglobulinemia patients with biopsy-proven liver involvement (P < 0.01) and with increased serum transaminase levels (p < 0.01). HCVAb were virtually absent in control patients with other immunologic diseases. These results support the notion that viral agents, i.e., HCV and possibly HBV, have a role in the pathogenesis of mixed cryoglobulinemia patients.

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