Expression of Cell-Adhesion Molecules in the Salivary Gland Microenvironment of Sjögren's Syndrome
Article first published online: 9 DEC 2005
Copyright © 1992 American College of Rheumatology
Arthritis & Rheumatism
Volume 35, Issue 1, pages 62–66, January 1992
How to Cite
Clair, E. W. S.T., Angellilo, J. C. and Singer, K. H. (1992), Expression of Cell-Adhesion Molecules in the Salivary Gland Microenvironment of Sjögren's Syndrome. Arthritis & Rheumatism, 35: 62–66. doi: 10.1002/art.1780350110
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Accepted: 12 AUG 1991
- Manuscript Received: 25 APR 1991
- NIH. Grant Number: AR-39162
Objective. The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue.
Methods. Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques.
Results. In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation.
Conclusion. In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.