Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis
Article first published online: 9 DEC 2005
Copyright © 1992 American College of Rheumatology
Arthritis & Rheumatism
Volume 35, Issue 5, pages 550–556, May 1992
How to Cite
Russell, I. J., Vaeroy, H., Javors, M. and Nyberg, F. (1992), Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis & Rheumatism, 35: 550–556. doi: 10.1002/art.1780350509
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Accepted: 2 JAN 1992
- Manuscript Received: 13 MAR 1991
- Upjohn Company
Objective. To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.
Methods. Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection.
Results. CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.
Conclusion. A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.