A Controlled study of the prevalence of cognitive dysfunction in randomly selected patients with systemic lupus erythematosus
Version of Record online: 9 DEC 2005
Copyright © 1992 American College of Rheumatology
Arthritis & Rheumatism
Volume 35, Issue 7, pages 776–782, July 1992
How to Cite
Ginsburg, K. S., Wright, E. A., Larson, M. G., Fossel, A. H., Albert, M., Schur, P. H. and Liang, M. H. (1992), A Controlled study of the prevalence of cognitive dysfunction in randomly selected patients with systemic lupus erythematosus. Arthritis & Rheumatism, 35: 776–782. doi: 10.1002/art.1780350711
- Issue online: 9 DEC 2005
- Version of Record online: 9 DEC 2005
- Manuscript Accepted: 19 MAR 1992
- Manuscript Received: 7 JAN 1992
- Biomedical Research. Grant Number: RR-05951
- NIH. Grant Numbers: AR-36308, AR-07530
Objective. To investigate the prevalence of cognitive dysfunction in randomly selected patients with systemic lupus erythematosus (SLE).
Methods. Randomly selected, ambulatory patients with SLE (n = 49) or with rheumatoid arthritis (RA) (n = 40) completed neuropsychological tests. These included Associate Learning, Switching Attention, Continuous Performance, Associate Recall, Hand–Eye Coordination, Pattern Comparison, Pattern Memory, the Stroop Color and Word Test, and the Symptoms Checklist–90R. Results were evaluated by multiple linear regression analysis.
Results. SLE patients had poorer performance than RA patients on the test of attention (P = 0.002) and tests of visuospatial ability (P = 0.03 and P = 0.04), independent of age, education, or steroid use. The conservative level of statistical significance, adjusting for multiple comparisons, was 0.005. SLE patients reported more symptoms of cognitive difficulty.
Conclusion. Cognitive dysfunction is common in ambulatory SLE patients as measured by standardized tests and is a cause of distress and impaired functioning. Self-reported cognitive difficulty appears to correlate with objective performance.