Ankylosing spondylitis in rochester, minnesota, 1935–1989. Is the epidemiology changing?

Authors

  • Laura D. Carbone MD,

    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    Search for more papers by this author
  • Cyrus Cooper MD,

    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    Search for more papers by this author
  • Clement J. Michet MD,

    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    Search for more papers by this author
  • Elizabeth J. Atkinson MS,

    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    Search for more papers by this author
  • W. Michael O'Fallon PhD,

    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    Search for more papers by this author
  • L. Joseph Melton MD

    Corresponding author
    1. Department of Health Sciences Research, and the Division of Rheumatology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota
    • Section of Clinical Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905
    Search for more papers by this author

Abstract

Objective. To determine trends in the incidence and clinical presentation of ankylosing spondylitis first diagnosed between 1935 and 1989 among residents of Rochester, Minnesota, and in the survival of the patients.

Methods. Population-based descriptive study.

Results. The overall age- and sex-adjusted incidence rate was 7.3 per 100,000 person-years (95% confidence interval 6.1–8.4). The rate tended to decline between 1935 and 1989, but there was little change in the age at symptom onset or diagnosis over the 55-year study period. Overall survival was not decreased up to 28 years following diagnosis.

Conclusion. These data indicate that there is a constancy in the epidemiologic characteristics of ankylosing spondylitis and suggest that previously study results indicating changes may have been due to biases in patient selection and study design.

Ancillary